Neutrophil Recruitment/Adhesion
Endothelial cell inflammatory response to endotoxin needs actin polymerization
Published in Blood Weekly, July 3rd, 2003
"Endotoxin-induced intercellular adhesion molecule-1 (ICAM-1) and IL-8 production in endothelial cells, which is mediated by Toll-receptor signaling, is essential for optimal neutrophil recruitment and migration during sepsis. Endotoxin also causes stress fiber polymerization that has recently been shown to affect intracellular signaling. However, the role of this polymerization process on endothelial-induced neutrophil adhesion and migration is unknown," investigators in the United States report.
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Source: Blood Weekly (2003-07-03)
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