Pretransplant Transfusion

Tolerization appears to happen after what would seem to be a normal Th1 response

Published in Blood Weekly, July 3rd, 2003

Tolerization induced by pre-transplant blood transfusion happens after what would appear to be a normal Th1 response.

"Donor-specific blood transfusion (DSBT) promotes graft acceptance in certain experimental and clinical situations. However, the exact nature of the operating mechanisms, and in particular the role of Th1/Th2 cytokines, remains controversial. We recently described a fully mismatched rat combination [RA rat (RT1p) to PVG rat (RT1c)] in which a single pre-transplant (Tx) DSBT induces donor-specific tolerance following heart transplantation (Htx)," scientists writing in the journal Transplant International report.

"In order to...

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Source: Blood Weekly (2003-07-03)

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