Published in Blood Weekly, July 10th, 2003
"Although the existence of mammary stem cells has been suggested by serial transplantation studies in mice, their identification has been hindered by the lack of specific surface markers, and by the absence of suitable in vitro assays for testing stem cell properties: self-renewal and ability to generate differentiated progeny," researchers in the United States explained.
To provide an assay capable of identifying mammary stem cells, G. Dontu and coauthors at the University of Michigan "developed an in vitro cultivation system that allows for propagation of human mammary epithelial cells...
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