Transplantation Tolerance

Study: Cellular and humoral sensitization against donor tissue should be tested

Published in Blood Weekly, July 10th, 2003

Little is known about the effect of an individual's immune history on their response to a donated tissue transplant. Now a study by researchers at Emory University in Atlanta, Georgia, reveals that individuals harboring virally-induced memory T cells that are cross-reactive with donor antigens are resistant to conventional strategies designed to induce transplant tolerance.

Enormous progress has been achieved in the field of transplantation during the past 3 decades, due in large part to the availability of effective immunosuppressive drugs. Such drugs are designed to sufficiently suppress the recipient immune response to the donor tissue without compromising the...

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Source: Blood Weekly (2003-07-10)

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