Hematology

The newly identified gene ZFP91 may be linked to acute myelogenous leukemia

Published in Blood Weekly, July 17th, 2003

"To elucidate mechanisms leading to acute myelogenous leukemia (AML), to find sensitive markers and novel targets for drug therapy, and to allow choice of suitable chemotherapy for each affected individual, we previously compared expression of mRNA from mononuclear cells of AML patients with that of normal controls using a cDNA microarray," researchers in Japan reported.

"Data from that study identified many genes that were commonly up- or down-regulated in AML cells. Of these, we report here the identification of a novel gene whose expression was increased in 27 (93%) of the 29 AML cases whose PBMC preparations include >70% leukemia cells," said M. Unoki and...

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Source: Blood Weekly (2003-07-17)

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