Stem Cell Research
Cord blood B-cell progenitors are multipotent prior to Pax-5 expression
Published in Blood Weekly, July 17th, 2003
Scientists working at France's National Institute of Health and Medical Research (INSERM) achieved "the molecular and functional characterization of very early interleukin 7 receptor alpha (IL-7Ralpha)+-CD79a+CD19- B-cell progenitors, produced by human CD34+CD19-CD10- cord blood cells grown in the presence of stromal cells and cytokines."
"Purified IL-7Ralpha+CD79a+CD19- cells transcribed the B-lymphoid specific genes E2A, EBF, TdT, Rag-1, had initiated DJ(H) rearrangements, but almost lacked Pax-5 mRNA," D. Reynaud and coauthors...
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Source: Blood Weekly (2003-07-17)
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