Non-Hodgkin's Lymphoma

MALT1 may be a dominant oncogene that plays a role in the pathogenesis of B-NHL

Published in Blood Weekly, July 24th, 2003

MALT1 may be a dominant oncogene that plays a role in the pathogenesis of B-NHL.

"The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated, lymphoid tissue (MALT) lymphoma," investigators in England report.

"Here, we show that deregulated MALT1 expression may occur in B-cell non-Hodgkin lymphoma (B-NHL) of various histologic subtypes either through translocation to the immunoglobulin heavy chain (IGH) locus or by genomic amplification, wrote D. Sanchez-Izquierdo and colleagues, University of Leicester, MRC.

"First, two cases, one case of MALT lymphoma and another of...

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Source: Blood Weekly (2003-07-24)

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