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Hematology

Angiogenic cytokine is overexpressed in myelofibrosis with myeloid metaplasia

Published in Blood Weekly, July 31st, 2003

Angiogenic cytokine is overexpressed in myelofibrosis with myeloid metaplasia.

According to published research from the United States, "bone marrow specimens from 11 patients with myelofibrosis with myeloid metaplasia (MMM) and seven normal controls were studied immunohistochemically to determine expression of transforming growth factor beta(TGF-beta), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and corresponding receptors."

"Staining distribution and intensity for TGF-beta, PDGF, VEGF, TGF-beta type II receptor, a receptor for PDGF, and receptors for VEGF and bFGF were...

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