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Stem Cell Transplantation

Antithymocyte globulin-based T-cell depletion reduces GVHD rate in multiple myeloma patients

Published in Blood Weekly, July 31st, 2003

Antithymocyte globulin-based T-cell depletion lowers the risk of graft-versus-host reactions in multiple myeloma patients undergoing stem cell transplantation.

Researchers in Germany examined the "toxicity and efficacy of in vivo T-cell depletion with anti-thymocyte globulin (ATG) as part of an intensified myeloablative conditioning regimen followed by allogeneic stem cell transplantation in patients with advanced multiple myeloma."

"The conditioning regimen consisted of modified total body irradiation, busulfan and cyclophosphamide (n=15) or in the case of prior dose-limiting radiotherapy of busulfan and cyclophosphamide (n=3)," noted N. Kroger and...

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