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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . August 7th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem Cell Transplantation - GVHD prophylaxis with antithymocyte globulin does not increase leukemia relapse risk

Stem Cell Transplantation - MxA protein can be used to distinguish viral infection from GVHD

Stem Cell Research - Novel cell lines aid study of germinal center B cell development

Stem Cell Research - Pulmonary side population cells characterized

Transfusion Medicine - Erythropoietin lowers transfusion needs during hematological cancer-induced anemia

Umbilical Cord Blood - Erythrocyte production through cord blood stem cell expansion may be feasible

Acute Myeloid Leukemia - Immunotherapy effective for relapsed stem cell transplant recipients

Atherosclerosis - Age-related stem cell loss prevents artery repair

Biomarkers - Plasma P-selectin levels rise in people with chronic liver diseases

Bloom Syndrome - One of 3 BLM helicase complexes, BRAFT, contains 5 Fanconi anemia proteins

Borrelia Burgdorferi - Telomere resolvase, ResT, is a positionally dependent tyrosine recombinase

Breast Cancer - Risk higher for young women with Hodgkin disease treated with radiation

Breast Cancer - Swenerton score useful for selecting high-dose chemotherapy and stem cell transplant candidates

Cell Differentiation - Researchers find mechanism that may determine early blood cell fate

Chemotherapy - Acute respiratory failure with diagnosis of monocytic leukemia has poor outcome

Chronic Myeloid Leukemia - Shelf registration statement filed; data on blood cancer therapy released

Chronic Myeloid Leukemia - Stem cell transplantation shortly after imantinib treatment may exacerbate skin toxicity

Colorectal Cancer - Macrophage colony-stimulating factor can act as colorectal tumor marker

End-of-Life Issues - Skills in palliative care are important for appropriate end-of-life care

Heart Transplantation - Tacrolimus dose must be altered in some cases of CYP3A5, MDR1 gene polymorphism

Hematology - Scientists confirm a link between hepatitis C virus and non-Hodgkin lymphoma

Hematology - VEGFR-2 maintains hematopoietic progenitor cell survival

Homeostasis - Neutrophils respond to cytokine withdrawal for apoptosis following infection

Iron Absorption - HFE and transferrin receptor TfR2 act together in intestinal crypt cells

Kidney Transplantation - Epstein Barr viral load can fluctuate without development of PTLD

Leukemia - Anti-CD66 mAb superior to anti-CD45 for pre-stem cell transplantation radioimmunotherapy

Leukemia - BCR/ABL blast amplification may have role in blast transformation

Leukemia - Chlorambucil given for at least a year does not affect cytogenetic parameters

Leukemia - Dexrazoxane and anthracyclines lead to a synergistic cytotoxic response in AML

Leukemia - Mast cells trigger apoptosis in Jurkat cells

Leukemia - Real-time reverse transcriptase-PCR measures SIL-TAL1 fusion gene transcripts

Leukemia - Sequential chemotherapy is effective for newly diagnosed de novo AML

Lymphoma - EBV + T-cell Asian lymphoma may have prognostic correlations

Lymphoma - Monitoring of the TNF-alpha levels may be a useful prognostic marker

Lymphoma - Murine models are useful for studying human lymphoid neoplasias

Lymphoma - Renal failure results from non-Hodgkin lymphoma infiltration of the kidneys

Macrophage Activation - Gram-negative bacteria activate toll-like receptor TLR4, production of IL-12

Malaria Therapy - Novel blood test provides accurate measure of pyronaridine levels

Neurological Disease - The spectrum of disease that human parvovirus B19 infection causes is very broad

Obstetrics - Subchorionic hematomas suggest underlying maternal circulation disorder

Oncology - Tissue factor/factor VIIa inhibitors don't use hemostasis to stop angiogenesis

Personnel - William Weed to lead search committee for new CEO of New York Red Cross

Policy - EC proposes strict ethical guidelines on E.U. funding of embryonic stem cell research

Psoriasis - Whole blood has higher levels of Th1 lymphocytes and serum IFN-gamma

Renal Cell Carcinoma - TRAIL and gamma-radiation apoptosis is impaired by deficient caspase-9 cleavage

Spinal Cord Injury - Neural stem cells secrete neurotrophic factors and promote axon growth

Squamous Cancer - PD-ECGF causes head and neck cancers to cycle through growth phases quickly

Stem Cell Research - Astrocyte-derived factors induce neuron differentiation from embryonic cells

Stem Cell Research - Company reports successful derivation of osteoblasts from hESCs

Stem Cell Research - Different Notch signaling pathways control T- and B-cell commitment

Stem Cell Research - Gene expression and engraftment capacity of hematopoietic cells linked to cell cycle phase

Stem Cell Research - Hematopoietic stem cells ferry exogenous genes directly to tumor vessels

Stem Cell Research - Neurokinin receptor crosstalk helps regulate hematopoiesis

Stem Cell Research - New technique can reprogram adult blood cells to be heart or nerve tissue

Stem Cell Research - Novel nonreceptor protein tyrosine kinase identified with inhibitory effects on Ras signaling

Stem Cell Research - Novel transcription factor plays key role in embryonic cell expansion

Stem Cell Research - Retinoic acid suppresses bone marrow mesenchymal stem cell growth

Stem Cell Research - Swine neuroepithelial stem cells could be useful for transplantation

Stem Cell Research - Tetratricopeptide repeat motif-containing proteins involved in neural stem cell RNA processing

Stem Cell Research - VEGF is the principal angiogenic modulator during new bone formation

Stem Cell Transplant - AMD-3100 granted orphan drug designation

Stem Cell Transplantation - Effects of prophylactic donor leukocyte infusions elucidated

Stem Cell Transplantation - Fasciitis can be manifestation of graft-versus-host disease

Stem Cell Transplantation - Ganciclovir can prevent post-transplant adenovirus infections

Stem Cell Transplantation - MRSA colonization should be eradicated before stem cell allografting

Stem Cell Transplantation - Stem cell allografts ineffective for pediatric X-linked agammaglobulinemia patients

Stem Cells - Neural cells are not rejected when transplanted

T-Cell Function - Dysfunction or dysregulation leads to immunodeficiency or autoimmune disease

Transplant Tolerance - Apoptosis of alloreactive T cells may play a role in tolerance initiation

Trisomy 21 - Fetal trisomy 21 diagnosis can be obtained noninvasively from maternal blood

Tuberculosis Diagnosis - PCR assay provides fast, simple, and accurate tuberculosis diagnosis in HIV-negative patients

Vasculitic Skin Lesions -  Strongyloides stercoralis rash should be ruled out before corticosteroid use

Vector Development - Dual promoters enable lentiviral vectors to generate coexpressed transgenes

Vector Development - Nucleofection is efficient for nonviral transfection of monocytic cells

Virology - Compounds show promise against Flavivirus and animal applications

Virus Management - Company focuses on host immune response, not the virus

West Nile Virus - Antisense drug for West Nile manufactured for clinical trials

West Nile Virus - FDA grants clearance to diagnostic test for West Nile Virus

West Nile Virus - Quality control system selected for Procleix clinical trials

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