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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . August 14th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem Cell Transplantation - KIR ligand incompatibility improves survival of unrelated stem cell graft recipients

Stem Cell Transplantation - Postprogenitor cell retransfusion prevents neutropenic fever in stem cell autograft recipients

Blood Substitute - Cholesterol protects against oxidative stress in hemosomes

Transfusion Medicine - AastromReplicell system useful for ex vivo cord blood stem cell expansion

Transfusion Medicine - Novel culture enables efficient expansion of Valpha24+ T cells

Transfusion Medicine - Unrelated cord blood transplantation effective for advanced myelodysplastic syndrome patients

Anemia - Anemia elevates risk of physical decline in older people

Anemia and Cancer - Anemia in cancer patients can be treated with transfusion, erythropoietin

Anemia and Cancer - Anemia of cancer can occur before any treatment begins

Atherosclerosis - Patients with Chlamydia pneumoniae have specific Th1 cells in plaque

B-Cell Generation - Bcl11a (Evi9) is an essential component for proper immune system development

Bacterial Pathogenicity - Listerial invasiveness occurs due to listeriolysin O mediated calcium influx

Blood Safety - Authorities search for HIV-stricken blood sellers

Blood Safety - High HTLV-1 rate confirmed in blood donors from Iranian city

Blood Testing - Novel assay useful for measuring platelet function in different lab animal species

Cardiology - PAR transgenes offer insight into the role of thrombin in vascular pathology

Chronic Myelogenous Leukemia - Imantinib enhances antileukemia effect of dendritic cells

Chronic Myelogenous Leukemia - Imatinib treatment does not eradicate malignant stem cells in CML patients

Chronic Myeloid Leukemia - Canadian phase I/II study for Theralux completed

Emergency Medicine - Rice University researchers makes first rapid, sensitive whole-blood immunoassay

Grasbeck-Imerslund Disease - Proteinuria is due to lack of cubulin function in reabsorbing some proteins

Hematology - Gene transduction improves the use of radiation against multiple myeloma

Hematology - Product line expanded with Cell-Dyn system

Hematology - Siglec-8 activation induces eosinophil apoptosis

Hemolytic Anemia - Pregnant women with dehydrated hereditary stomatocytosis risk fetal hydrops

Hemolytic-Uremic Syndrome - Stx2-specific monoclonal antibodies show promise for treating Stx2 variants

Hemophilia - New model estimates global demand for hemophilia A treatment

Hodgkin Disease - Cutaneous granulomas appear as the first manifestation of Hodgkin's disease

IgA Nephropathy Risk - Henoch Schonlein purpura may not fully resolve, IgA present years later

Immunology - Data about B cell lymphoma vessel density hinges on staining specifics

Immunology - Heightened CCR4 expression plays key role in CD25+ suppressor T-cell homing

Immunology - Some T-cell and immunological defects might stem from VEGF overexpression

Intracerebral Hemorrhage - Thrombin exposed macrophages produce MMP-12, minocycline reduces pathology

Iron in Blood - Persons with abnormal iron status may have hereditary hemochromatosis mutation

Kidney Transplant - Adenovirus-produced pyelonephritis is a possible risk for pediatric patients

Kidney Transplant - Long-term functional study shows decline in half, improvement in a third of recipients

Leukemia - Adenine analogs may be differentiation therapy agents for acute myeloid leukemia

Leukemia - Insertion of MLL sequences is a rare abnormality associated with infant leukemia

Leukemia - Neurologic complications occur in children receiving L-asparaginase for ALL

Leukemia and Lymphoma - B cells with aberrant markers along with CD19 indicate increased patient risk

Link Module Superfamily - TSG-6 has anti-inflammatory functions in extracellular matrix and in blood

Lymphocytosis - HLA-I receptors present on natural killer cells silence their own action

Lymphoma - CHASE effective as salvage chemotherapy regimen for lymphoma patients

Lymphoma Therapy - Stem cell transplantation successful in patient with central nervous system lymphoma

Lymphopoiesis - Alpha beta T lymphocyte development depends on Bcl11b

Lymphoproliferation - Autoimmune lymphoproliferative syndrome mutation can cause glomerulonephritis

Lymphotropic Herpesviruses - Antiviral susceptibility utilizing flow cytometry is an efficient testing method

Psoriasis - T-cell behavior can be managed by several routes; therapy must be safe long term

Pulmonary Embolism - Many laboratory tests can aid in diagnosis, but imaging is best

Pulmonary Medicine - Runaway angiogenesis after lung transplantation can lead to hemangiomatosis

Pulmonary Thromboembolism - Mortality rate decreased approximately 30% from 1979 to 1998

Pulmonary Tuberculosis Diagnosis - Interferon gamma levels in whole blood can help determine tuberculosis severity

Red Cell Enzymopathy - G6PD deficiency has a new variant, 989 CGC->CAC (330 Arg->His) mutation

Septic Shock - Mortality decreases while frequency increases

Septicemia - Fish oil i.v. infusion alters cytokines, plasma lipids, lymphocyte membranes

Stem Cell Research - CD26 plays role in G-CSF-induced stem cell mobilization

Stem Cell Research - Embryonic stem cells form tumors when implanted in murine peritoneal cavity

Stem Cell Research - Endothelial progenitor cell tumor homing relies on multiple steps for fruition

Stem Cell Research - Homeodomain protein play key role in platelet differentiation

Stem Cell Research - Neural stem cells have unexplored angiogenic potential

Stem Cell Research - Platelet factor 4 directly and indirectly suppresses hematopoietic stem cell activity

Stem Cell Research - Sonic hedgehog, FGF8 induce dopaminergic phenotypes in neural stem cells

Stem Cell Transplantation - Anti-TCRalphabeta monoclonal antibody effective for T-cell ablation in canine model

Stem Cell Transplantation - Automated assay useful for identifying stem cell recipeints with high CMV disease risk

Stem Cell Transplantation - Renal dysfunction in pediatric stem cell graft recipients characterized

Stem Cells - $1.2 Million awarded to convert adult bone marrow cells into brain cells

T-Cell Allorecognition - T cells factors involved in the final outcome of transplant rejection

Takayasu Arteritis - A patient treated for years with prednisolone developed antibody abnormalities

Transplant Medicine - Infusion of customized regulatory T cells may control transplant rejection

Transplant Medicine - Passenger leukocyte tolerance induction could be harnessed to reduce rejection

Transplant Medicine - Porcine endogenous retrovirus detected in porcine bone marrow cells

Transplant Medicine - The 4-1BB pathway may be involved in allograft rejection caused by CD8+ T cells

Transplantation - Plasmapheresis relieves a liver transplant-related cutaneous fibrosing disorder

Trypanosoma Cruzi - Alpha-L-fucosidase is present in several stages, may associate with membranes

Tuberculosis Diagnosis - Novel PBMC-based tuberculosis immunoassay fast, accurate

Vascular Damage - Vascular thrombosis is a risk factor in acute cytomegalovirus infection

Virology - Current infectious diseases threats discussed

Virology - HIV, HCV license agreement granted for plasma testing

Virology - Hepatitis B virus polymerase associates with leukemia nuclear bodies via p11

West Nile Virus - Clinical trial site intercepts first unit of infected blood

West Nile Virus - Florida blood bank detects West Nile virus in donor

West Nile Virus - New West Nile virus control targeted to clinical laboratories

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