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Transplant Medicine

Porcine endogenous retrovirus detected in porcine bone marrow cells

Published in Blood Weekly, August 14th, 2003

Porcine endogenous retrovirus was detected in cultures of freshly isolated porcine bone marrow cells.

"Pigs are under consideration as possible sources of organs for xenotransplantation in humans. The induction of hematopoietic microchimerism through xenotransplantation of source animal hematopoietic cells has been suggested as a means to induce tolerance in potential recipients," researchers in the United States report.

"Because all porcine cells contain genetic information for porcine endogenous retrovirus (PERV), coculture techniques, reverse transcriptase (RT), and reverse transcriptase-polymerase chain reaction assays were used to determine...

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