Juxtaglomerular Apparatus

Phospholemman and similar protein are separate in extraglomerular mesangium

Published in Blood Weekly, August 21st, 2003

Phospholemman is a membrane protein homologous to the gamma subunit of sodium-potassium ATPase, but although it is localized in extraglomerular mesangial cells, it is separate from Na, K-ATPase gamma.

According to a study from the United States, "The molecular mechanisms with which the juxtaglomerular apparatus accomplishes its twin functions, acute regulation of glomerular blood flow and secretion of renin, are still not clearly understood. Least understood is the role of the extraglomerular mesangial (EM) cells, also known as lacis or Goormaghtigh cells, which lie sandwiched between the macula densa and the afferent and efferent arterioles.

"We...

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Source: Blood Weekly (2003-08-21)

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