Hematology
Novel suicide fusion genes stem T cell reactions after transplantation
Published in Blood Weekly, September 4th, 2003
"Donor lymphocyte infusions (DLI) following allogeneic stem cell transplantation are known to mediate graft-versus-leukemia effect (GVL). A major side effect of these immunotherapies is the development of graft-versus-host diseases (GVHD). One promising approach to prevent GVHD is to genetically modify donor T cells with a suicide mechanism that can be induced in the case of GVHD," scientists writing in the journal Gene Therapy report.
"Here we report on a retroviral vector containing the death effector domain (DED) of the human Fas-associated protein with death domain...
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Source: Blood Weekly (2003-09-04)
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