Hypoxia enhances bone marrow hematopoietic cell activity

"It has been proposed that bone marrow (BM) hematopoietic stem and progenitor cells are distributed along an oxygen (O-2) gradient, where stem cells reside in the most hypoxic areas and proliferating progenitors are found in O-2-rich areas," researchers in the United States explained. "However, the effects of hypoxia on human hematopoietic stem cells (HSCs) have not been characterized."

G.H. Danet and colleagues at the University of Pennsylvania conducted a study "to evaluate the functional and molecular responses of human BM progenitors and stem cells to hypoxic conditions."

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