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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 11th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Substitute - Novel oxygen carrier may improve stroke treatment

Fanconi Anemia - Minimal conditioning safe, effective for FA patients undergoing stem cell transplantation

Cancer Therapy -  Gleditsia sinensis fruit extract has antiangiogenic potential

Hematology - Abnormal hemoglobin carriers identified by low glycohemoglobin levels, genetic screening

Pulmonary Complications - Lymphomatoid granulomatosis is a risk following renal transplant

Stem Cell Transplantation - Factors involved in post-transplant IIP identified

Anesthesiology - Opioids play a role in immunosuppression; clinical relevance remains unclear

Antigen Presentation - ApoE may reduce T cell activation by reducing APC stimulatory molecules

Autophagy Phenomenon - Intracellular pathogens like Listeria monocytogenes can be targeted

B-Cell Activation - Extrafollicular antibody response is different than intrafollicular

Blood Safety - Blood, pooled plasma will be screened for parvovirus B19 in the Netherlands

Breast Cancer - Most breast lymphomas should be treated initially with CHOP-like chemotherapy

Childhood Leukemia - Diagnostic x rays, DNA repair genes, and childhood ALL need more study

Collaborations - Hematology contract agreement signed by purchasing group

Erythroid Colony Formation - Thioredoxin, which protects marrow from peroxide, is deactivated by IFNgamma

Finance - Blood products company reports steady revenue, slightly higher losses in Q2

Finance - Company puts focus on acquiring new technologies, initiating R&D

Finance - Global Med reports earnings of $0.02 per share for second quarter

Finance - Second quarter net income down at Dialysis Corp. of America

Follicular Lymphoma - Anthracyclines did not appear to influence survival or disease relapses

Hematology - Contact-dependent signaling occurs during late events of platelet activation

Hematology - LDL receptor-related protein plays diverse role in protease clearance

Hematology - New genetic engineering techniques are likely to cure hemophilia patients

Hematology - SCL/Tal-1 plays key role in erythroid cell development

Hemophilia - Factor VIII gene therapy rights retaken from Wyeth

Immune Complications - Evans syndrome may be associated with ulcerative colitis

Immune Evasion - Measles virus V protein interferes with host interferon production

Immunology - BAFF protects Ig-producing plasmablasts arising from memory B cells

Immunology - IL-3 blocks osteoclast precursor differentiation irreversibly

Immunology - The role of anticardiolipin antibodies in chronic viral hepatitis is undefined

Infectious Disease - IBM to help find genetic links to immune system diseases

Infectious Disease Diagnosis - TaqMan-based blood test provides rapid Candida albicans detection

Kidney Disease - Acute interstitial nephritis can lead to renal failure, yet little is known

Kidney Transplant - Renal allografts surviving 20 yrs tend to have some histological damage

Leukemia - Cladribine is not worthy of further investigation in adult T-cell leukemia

Leukemia - Reactive oxygen species are essential mediators in BTS-induced apoptosis

Leukemia and Lymphoma - Childhood ALL may peak in the autumn-winter seasons in Iran

Liver Cells - MultiCell Technologies awarded SBIR grant to identify drug candidates

Lymphoblastic Leukemia - Patients who didn't have radiation survive as long as general population

Lymphoma - Deregulated expression of BCL6 may allow lymphoma cells to resist chemotherapy

Mantle Cell Lymphoma - PS-341 and BAY 11 induce apoptosis by inhibiting NF-kappa B activation

Memory Cell Persistence - IL-7, T cell receptor are involved in maintenance of CD4 memory cells

Multiple Myeloma - Thalidomide back on the market in Australia by year-end

Nasal/Paranasal Lymphoma - Local-regional radiation and systemic chemotherapy is recommended

Natural Antibacterial - The peptidoglycan recognition protein M.mPGRP-L has good antibacterial activity

Nephrology - Maternal iron restriction in rodent pregnancy leads to offspring hypertension

Neuroscience - Class II HDAC mRNA upregulated during rat hippocampal progenitor differentiation

Neutropenia - Oral antibiotics, early hospital discharge manage low-risk febrile neutropenia

Obstetrics - Intrapartum management of women on anticoagulation therapy requires planning

Oncology - Radiofrequency ablation generates 'thermal fixation' of liver cancer

Ophthalmology - Restored sight case reveals extent to which vision depends on learning

Osteoporosis - Recombinant human PTH 1-34 appears to reduce bone fractures

Parkinson Disease - Adult mouse bone marrow stem cells can become cells of the nervous system

Personnel - Claire J. Lockey named VP, regulatory affairs

Personnel - Jacob Rowe to chair stem cell company's scientific advisory board

Personnel - John A. Harris joins board of instrumentation company

Polycythemia Vera - Stem cells from PV patients characterized

Renal Cell Carcinoma - Polymorphisms of the ERalpha gene may be associated with renal cell cancer

Renal Cell Carcinoma - bHLH-LZ subfamily may be critical in regulating (aberrant) renal cellular growth

Respiratory Distress - Generalized lymphangiectasia in infants can be relieved by puncture

Sepsis/Septic Shock - Antiendotoxin IgM antibody increases correlate with survival from septicemia

Septicemia - Immunocompromised patients' natural flora is main culprit for septicemia

Specimen Collection - FDA gives clearance to market CellSave Preservative Tube

Stem Cell Research - CBP and p300 regulate chondrocyte activity through Sox9 activation

Stem Cell Research - Chemokines involved in CD34+ cell recruitment to injured liver identified.

Stem Cell Research - Cyclic strain induces matrix mineralization by bone stem cells

Stem Cell Research - Neuropeptide Y enhances proliferation of hippocampal neuron precursors

Stem Cell Research - Novel selection method improves isolation of murine embryonic stem cells

Stem Cell Research - TNF-alpha induces immature Langerhans cell generation in umbilical cord blood

Stem Cell Transplantation - Pentostatin shows promise for treatment of refractory chronic GVHD in children

T-Cell Activation - The transition from naive T cells to effectors involves two receptor switches

Thrombocytopenia - Argatroban reduces thrombosis, death due to thrombosis

Transplant Rejection - If antibodies are the true problem in transplant rejection, removal should work

Transplantation - Stress before liver surgery is milder in donors than in liver disease patients

Trypanosoma Brucei - RNA polymerase I transcribes not just rDNA; but also procyclin, VSG genes

Visceral Surgery - Toll-like receptor-4 mutation D299G does not increase susceptibility to sepsis

Wegener Granulomatosis - Staphylococcal superantigens are not responsible for activated T cells

West Nile Virus - Agreement signed to continue development of methylene blue

West Nile Virus - Mayo publishes review on clinical presentation, diagnosis

West Nile Virus - Thirty-five sites will test new drug

Wound Healing Proteins - Notice of allowance of European patent granted for CryoSeal FS System

X-Linked Agammaglobulinemia - Lack of Btk expression in dendritic cells doesn't alter their function

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