Erythroid Colony Formation

Thioredoxin, which protects marrow from peroxide, is deactivated by IFNgamma

Published in Blood Weekly, September 11th, 2003

Anemic conditions appear to correlate with oxidative stress; peroxide does inhibit blood derived erythroid colony formation, but bone marrow colony formation is protected by thioredoxin; however, it is in turn deactivated by IFNgamma.

"Evidence of increased oxidative stress is a hallmark of many chronic diseases associated with anemia. The current study was undertaken to evaluate the effects of oxidative stress on erythroid colony formation in vitro by bone marrow light density mononuclear cells (LDMN) and by peripheral blood derived cells enriched for erythroid colony forming units (CFU-E), and how these effects can be modified by a cytokine implicated in the anemia of...

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Source: Blood Weekly (2003-09-11)

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