Neuroscience

Class II HDAC mRNA upregulated during rat hippocampal progenitor differentiation

Published in Blood Weekly, September 11th, 2003

Class II HDAC mRNA is upregulated during the differentiation of rat hippocampal progenitor cells.

In a recent study, scientists in Finland examined "the expression of histone deacetylases (HDACs 1-10) mRNAs during early differentiation of cultured rat hippocampal progenitor cells using Northern blot analysis."

"Embryonic rat hippocampal progenitors were kept proliferating and undifferentiated (neurospheres) in the presence of mitogens and induced to stop proliferation and to differentiate into neurons and astrocytes by mitogen removal," explained F. Ajamian and coauthors at the University of Kuopio.

"We found two- to fourfold...

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Source: Blood Weekly (2003-09-11)

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