Transplant Rejection

If antibodies are the true problem in transplant rejection, removal should work

Published in Blood Weekly, September 11th, 2003

If antibodies are the problem in transplant rejection, then removal of them by immunosuppression may block rejection.

"According to the humoral theory of transplantation, antibodies cause allograft rejection. Publications are cited showing that antibodies: (1) cause hyperacute kidney rejection, (2) lead to C4d deposits associated with early kidney graft failures, (3) are a good indicator of presensitization leading to early acute rejections, (4) were present in 96% of 826 patients who rejected a kidney graft, (5) are associated with chronic rejection in 33 studies of kidney, heart, lung, and liver grafts, and (6) in 3 studies, appeared in the circulation before evidence...

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Source: Blood Weekly (2003-09-11)

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