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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 18th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem Cell Transplantation - Cord blood transplants improve long-term hematopoietic function

Transfusion Medicine - Diaspirin-crosslinked hemoglobin reduces perioperative transfusion needs

Acute Renal Failure - Natriuretic peptides that can help the kidney are increased in circulation

Blood Substitutes - PEG-Hb solution can extend cardiac preservation time

Crohn Disease - Autologous stem cell transplantation can lead to durable Crohn disease remission

Stem Cell Transplantation - Interleukin-1 degrades stem cell function after chemotherapy or radiation treatment

Stem Cell Transplantation - Stem cell labeling with large magnetic particles enables single-cell imaging

Adaptive Immunity - CCR7 and CXCR5 affect lymphocyte trafficking actions in lymphoid tissue

Artery Function - Atherosclerotic plaques cause artery walls to produce many more proteins

B-Cell Differentiation - The cell cycle plays an integral part in plasma cell biology and dysfunction

Biotechnology - Immuno-affinity expanded-bed adsorption effective for monocyte separation from whole blood

Biotechnology - Sulfamethazine useful for immunoglobulin G purification from human plasma

Blood Banking - Gambro TRIMA enables safe, automated blood component collection

Blood Preservation - Company files patent application for improved platelet storage

Blood Products - Novel blood purification membrane shows promise

Blood Safety - Human T-lymphotropic virus tax not found in New York City blood donors

Bone/Cartilage Formation - Smad5 is found in mitochondria when not involved in nuclear signaling

Brain Complications - Cerebral vasospasm following subarachnoid hemorrhage is inflammatory event

Cystic Fibrosis - Stem cells shown to regenerate damaged lung tissue for first time

Dengue Virus - Cross-reactivity found between dengue and Japanese encephalitis viruses

Dengue Virus - Dendritic cell entry is via viral envelope glycoprotein/DC-SIGN interaction

Diagnostics - New HIV rapid test is 100% accurate

Dialysis Complication - Beta2 -microglobulin unfolds easily; may induce amyloid fibril formation

Diffuse Alveolar Hemorrhage - Inflammatory bowel disease, thyroiditis, pulmonary siderosis can be linked

Ebola Virus - Accelerated Ebola vaccination schedule effective in non-human primates

Epidemiology - Lymphatic filariasis cannot be readily assessed only by hydrocele rate

Erythropoiesis - In terminal differentiation, there is increased Nix and Bcl-xL expression

Factor XI Deficiency - Two novel mutations involved in severe factor XI deficiency

HIV and AIDS - Elevated macrophage inflammatory protein 1 beta linked to placental malaria

HIV/AIDS Therapy - RNA-based gene therapy techniques show promise for HIV control

Hematological Cancer - Plasma cells can turn cancerous by at least six different mechanisms

Hematology - Modulation of the NO trans effect in heme proteins investigated

Hematology - Ochratoxin A damages human hematopoietic progenitor proliferation

Hepatic Regeneration - Macrophage inflammatory protein 2 aids regeneration after hepatectomy

Immune Response - B cells may use CD40 as a signal in germinal center or antibody formation

Immunology - Hepatitis B core antigen stimulates interleukin-18 production

Infectious Disease Therapy - Ramoplanin shows promise for treatment of vancomycin-resistant Enterococcus

Integrin Receptor Activation - Integrin receptor CD11b/CD18 can be easily modified to alter adhesiveness

Kidney Transplant - ELISPOT assay for IFN-gamma independently predicts future kidney function

Kidney Transplant Risk - HLA-G appears to be associated with a percentage of malignant skin lesions

Leukemia - Researchers identify genes that may be associated with prognosis

Liver Transplantation - Thrombosis-related mutation not linked to post-transplant HAT

Lung Diseases - CCL2 worsens lung inflammation; blocking activity may prove useful therapy

Lymphoblastic Leukemia - Reports of resistance to glucocorticoid-induced apoptosis evaluated

Lymphoma - Lymphomas are the most common nonepithelial head and neck cancers

MALT Lymphoma - Gene crucial for antibody-producing cell development is key to blood cell cancer

Multiple Myeloma - Australian panel recommends approval of thalidomide

Multiple Myeloma - Genetic analysis is necessary for detecting all changes creating disease

Multiple Myeloma - Ig translocations are common, but cyclin D dysregulation occurs in all

Multiple Myeloma - Method to predict survival in multiple myeloma developed

Neutrophil Expression - Neutrophil levels of NB1 GP are due to gene polymorphisms

Obstetrics - The mineral water Spatone offers pregnant women an alternative source for iron

Obstructive Sleep Apnea - Apnea produces changes in cytokines and blood gamma delta T cell attachment

Patents - U.S. patent for safety blood drawing device issued

Personnel - Peter Allen, Brian Concannon named division presidents of blood processing firm

Platelet Function - Platelet-collagen interaction, other functions center around GPVI receptor

Public Policy - Swedes in favor of genetic engineering but against spread of genetic information

Receptor Studies - ERK1/2 phosphorylation/activation by PAF receptor is endocytosis-independent

Research - Canada and U.S. launch collaborations in circulatory and respiratory health

Septicemia - Dendritic cells are reduced by apoptosis, may compromise B-, T-cell function

Sickle Cell Anemia - Children often don't receive antibiotics to prevent deadly infections

Stem Cell Banking - Competitive code of conduct developed for cell preservation industry

Stem Cell Research - BMP-4 promotes hematopoietic differentiation of embryonic stem cells

Stem Cell Research - Basic fibroblast growth factor promotes placental, cord blood stem cell expansion

Stem Cell Research - Bone-marrow-derived cells foster microvascular repair in injured kidneys

Stem Cell Research - Company reports successful engraftment of cardiomyocytes derived hESCs

Stem Cell Research - SPA-1 acts as tumor suppressor in hematopoietic cells

Stem Cell Transplantation - Alemtuzumab may increase EBV infection risk in stem cell graft recipients

Stem Cell Transplantation - Conditioning with fludarabine, targeted busulfan effective for stem cell graft recipients

Stem Cell Transplantation - Delayed G-CSF stem cell mobilization after chemotherapy may be feasible

Stem Cell Transplantation - Low TPO output by bone marrow cells may underlie GVHD-related thrombocytopenia

Stem Cell Transplantation - Mathematical model predicts neutrophil recovery after stem cell transplantation

Stock Repurchase - Dialysis services company extends stock repurchase program, increases amount to $250M

Therapy - New retinoic acid metabolizing cytochrome P450 discovered

Thrombosis - Targeting factor XI for antithrombosis may limit hemostatic impairment

Thrombosis Therapy - Platelet expression of fibrinolytic proteins has antithrombotic activity

Transfusion Medicine - Blood transfusions no longer standard treatment for severe anemia

Transfusion Medicine - Isoagglutinin testing may prevent passive ABO antibody-induced hemolysis after transfusion

Transplant Medicine - Antibody induction therapy lowers rejection in pancreas-kidney transplant

Transplant Medicine - Complement synthesis by kidney graft may influence transplant rejection

Transplant Medicine - Immunosuppressant FTY720 is effective in stable renal transplant patients

Transplant Medicine - The number of gamma delta T cells and level of IL-6 may help monitor outcome

Transplant Medicine - Transplant tolerance trials are moving slowly compared with T-cell depletion

Transplant Research - GM-CSF restores innate immunity cytokines in immunosuppressed human blood

Transplantation - Interferon causes sustained hepatitis C virus clearance in kidney recipients

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