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Stem Cell Transplantation

Cord blood transplants improve long-term hematopoietic function

Published in Blood Weekly, September 18th, 2003

Stem cell transplant patients who receive CB-derived grafts have better long-term hematopoietic function than marrow graft recipients.

"Delayed hematopoietic recovery is the main factor precluding a wider use of cord blood (CB) transplants," scientists in Italy explained.

F. Frassoni and colleagues at San Martino Hospital in Genova "hypothesized that this delayed engraftment might not be related to an insufficient number of stem cells in the graft, but to an intrinsic difficulty of these cells to undergo differentiation."

"To test our hypothesis, two groups of children were compared; 12 received a CB transplant and 12 an adult...

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