Dialysis Complication
Beta2 -microglobulin unfolds easily; may induce amyloid fibril formation
Published in Blood Weekly, September 18th, 2003
According to a study from Japan, "Although native beta2 microglobulin (beta2-m), the light chain of the major histocompatibility complex class I antigen, assumes an immunoglobulin domain fold, it is also found as a major component of dialysis-related amyloid fibrils. In the amyloid fibrils, the conformation of beta2-m is considered to be largely different from that of the native state, and a monomeric denatured form is likely to be a precursor to the amyloid fibril.
"To...
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Source: Blood Weekly (2003-09-18)
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