Hematology
Modulation of the NO trans effect in heme proteins investigated
Published in Blood Weekly, September 18th, 2003
"The binding of NO to the iron heme in guanylate cyclase and other heme proteins induces the cleavage of the proximal histidine bonded to the metal. In this study we assess by means of density functional theory (DFT) electronic structure calculations the role of H-bonding to histidine in the modulation of this effect," scientists in Argentina report.
"We have considered in the first place a model of the isolated active site coordinated with imidazole and imidazolate to mimic the effects of a very strong H-bond," said Marcelo A. Marti and...
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Source: Blood Weekly (2003-09-18)
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