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Kidney Transplant

ELISPOT assay for IFN-gamma independently predicts future kidney function

Published in Blood Weekly, September 18th, 2003

ELISPOT for interferon-gamma appears to be independent predictor of future renal function in kidney transplant.

"Post-transplant monitoring of cellular immunity might be useful in predicting longterm outcomes of kidney transplant recipients. We used an enzyme linked immunoabsorbent spot (ELISPOT) assay to serially measure the frequency of peripheral blood lymphocytes producing interferon-gamma in response to stimulator cells from donors or third parties in 55 primary kidney transplant recipients," scientists in the United States report.

"Mean frequencies measured during the first 6 mo after transplantation correlated significantly with the serum...

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