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MALT Lymphoma

Gene crucial for antibody-producing cell development is key to blood cell cancer

Published in Blood Weekly, September 18th, 2003

A gene that is crucial to the development and function of an entire family of immune cells is also key to understanding why one member of that family can become cancerous.

Investigators at St. Jude Children's Research Hospital and the Blood Research Institute at the Blood Center of Southeastern Wisconsin, Milwaukee, reported this finding in the September 2003 issue of Nature Immunology.

The St. Jude researchers had previously shown that one of these cell types, marginal-zone B cells, can give rise to a cancer called mucosa-associated lymphoid tissue (MALT) lymphoma when the cells abnormally overexpress a gene called Bcl10. The current finding...

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