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Leukemia

Functional markers could be helpful to predict clinical behavior of ALL

Published in Blood Weekly, September 25th, 2003

Expression of functional markers could be helpful to predict the clinical behavior of acute lymphoblastic leukemia.

According to published research from South Korea, "We analyzed surface antigens, multidrug resistance (MDR) parameters (PGP, MRP, LRP), tissue infiltration parameters (CD 18, CD44, VCAM, MMP2), receptors for colony stimulating factors (G-CSFr, GM-CSFr) and cell cycle parameters (Ki-67, topoisomerase IIalpha) in 86 patients with acute lymphoblastic leukemia (ALL).

"LRP, PGP and CD 18 were associated with poor clinical outcome, and LRP expression was related with CDI 8, CD44 and G-CSFr," wrote E.J. Oh and colleagues, Catholic University...

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