Lymphoma

Complement activation determines the therapeutic activity of rituximab in vivo

Published in Blood Weekly, September 25th, 2003

Complement activation determines the therapeutic activity of rituximab in vivo.

"Rituximab is an anti-CD20 chimeric mAb effective for the treatment of B-NHL. It can lyse lymphoma cells in vitro through both G and Ab-dependent cellular cytotoxicity. The mechanism of action of rituximab in vivo is however still unclear," scientists in Italy report.

"We have set up a new in vivo model in nonimmunodeficient mice by stable transduction of the human CD20 cDNA in the murine lymphoma line EL4. Animals injected i.v. with the EL4-CD20+ lymphoma cells died within 30 days with evident liver, spleen, and bone marrow involvement, confirmed by immunohistochemistry...

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Source: Blood Weekly (2003-09-25)

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