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Stem-Cell Transplantation

Haploidentical PBSCT based on fetomaternal tolerance feasible

Published in Blood Weekly, September 25th, 2003

Haploidentical stem-cell transplants based on fetomaternal tolerance is feasible.

According to a study from Japan, "a 31-year-old woman with advanced acute myeloid leukemia underwent non-T-cell-depleted (TCD) peripheral blood stem-cell transplantation (PBSCT) with a reduced-intensity conditioning regimen."

"The donor was an HLA haploidentical 3-loci-mismatched complementary sibling who had not inherited maternal HLA antigens," noted N. Uoshima and colleagues at Matsushita Memorial Hospital.

"Long-term fetomaternal microchimerism was detected by nested polymerase chain reaction with specific primer typing," they said....

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