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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . October 2nd, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem-Cell Transplantation - Intensive SCT conditioning regimen effective for high-risk leukemia patients

Stem-Cell Transplantation - Oral tolerance induction may reduce GVHD risk in stem-cell graft recipients

Blood Substitute - Novel LC-based assay detects Hemopure doping in athletes

Chronic Myeloid Leukemia - Stem cell transplantation benefits confirmed for pediatric CML patients

Stem-Cell Transplantation - Fludarabine-melphalan regimen increases post-SCT T-cell engraftment, GVHD risk

Stem-Cell Transplantation - Monthly chimerism analysis can predict stem-cell graft failure

Aging - CD8 T, CD16 NK have different telomere shortening rates, telomerase activity

Anemia - Hepcidin is critical for iron transport, macrophage iron collection

B Cell Differentiation - Transcription coactivator OCA-B gene may be involved in B-cell expansion

Bacteremia - Alpha-proteobacterium in an immunocompetent geriatric patient causes bacteremia

Blood Transfusion - Trials for investigational pathogen inactivation system halted

Cancer Histology - Primary central nervous system lymphoma can have cryoglobulin deposits

Cancer Therapy - Dosing regimens polarize the mobility and viability of vessel progenitor cells

Cardiac Testing - 10-Minute cardiac troponin I test receives U.S. FDA clearance

Cell Therapy - Novel source found in human embryonic stem-cell-derived cardiomyocytes

Cesarean Section - C-section has minor risk of maternal HSV-2 brain inflammation

Chronic Hepatitis C - Several hematologic disorders are linked to hepatitis C virus infection

Congestive Heart Failure - Stem cell therapy is a safe tool for mending broken hearts

Coronary Stenting - New data confirms safety of Lipitor in combination with anti-blood-clotting drug

Critical Care Medicine - C1 inhibitor benefits sepsis due to lowering of neutrophil activation

Deep Vein Thrombosis - FDA clears VIDAS D-Dimer New

Dengue Virus - NS1 serotype specific IgG ELISA distinguishes primary, secondary infection

Diagnostics -  Toxoplasma gondii ELISA can give false-positive IgM due to sphingolipids

Funding - Grant awarded to develop hepatitis C virus drug susceptibility assay

Gene Therapy - Lengthened targeting arms do not increase HR efficiency in stem-cell beta-globin locus

Genomics - Expression of the novel gene asrij overlaps with vascular markers

Graft-versus-Host Disease - Programmed death-1 is involved in protection from GVHD lethality

HIV Progression - Disease development can be monitored and predicted

Heart Disease Diagnosis - Stem-cell company provides cardiac risk assessment calculator

Heart Failure - Researchers describe stem-cell therapy for myocardial repair, regeneration

Hematology - Cytotoxic T lymphocytes can be generated ex vivo to target multiple myeloma

Hematology - Negative selection augments the characterization of bone marrow derivatives

Hysterectomy - Platelet populations become different after abdominal uterine removal

Immunogenetic Database - 89 Killer immunoglobin-like receptor alleles (KIR) have been sequenced

Immunotherapy - Divergent virology can affect the outcome of ex vivo T-cell expansion

Leukemia - Arsenic trioxide is effective against acute promyelocytic leukemia

Leukemia - Flavonoids can differentially modulate the efficacy of chemotherapeutics

Leukemia - Researchers validate the Hammersmith prognostic scoring system

Leukemia - Vigorous studies required for understanding, management of NK leukemia, lymphoma

Leukemia Therapy - Allogeneic SCT superior to autotransplantation for young leukemia patients

Leukemia Therapy - Chromosome 9 inversion linked to poor stem-cell transplantation outcome

Lymphoma - Cutaneous T- and B-cell lymphoma need subclassification, specific treatment

Lymphoma - Global patient organization launched to help millions with lymphoma

Melanoma - CD80+ B-cell levels may predict melanoma outcome

Melanoma - Positive, long-term, follow-up data reported from phase I trial of GVAX

Mergers and Acquisitions - Company discusses GenSci merger and announces plans to streamline

Mutiple Myeloma - Multiple myeloma patients may appear to have hyperphosphatemia due to artifact

Mycotoxins - Ochratoxin A and some metabolites alter kidney cell surface marker expression

Myelodysplastic Syndrome - Myelodysplastic syndrome may occur after acute promyelocytic leukemia

Myelodysplastic Syndrome - Philadelphia chromosome may be involved in bone marrow suppression

Myeloma - Plasmablastic transformation and acute leukemia can result from multiple myeloma

Neuroscience - Cerebral microvessel reactions vary in response to focal ischemia

Non-Hodgkin Lymphoma - Combined rituximab and G-CSF treatment yields long remission times

Nosocomial Infection -  Listeria moncytogenes cross-contaminates infants in a newborn nursery

Obstetrics - Several factors combine in late pregnancy to increase hemolytic uremic syndrome

Personnel - Mitchell Seyedin, PhD, named president and CEO of tissue-repair company

Personnel - PolyHeme maker names Eva C. Essig VP regulatory affairs

Proteolysis - Monocytes starved of glutamine during infection can't degrade all proteins

Proteomics - Structure dictates Hsp90 role in heme activator protein Hap1 activation

Renal Failure - Slovenian hemodialysis patients experience low viral hepatitis rates

Rickettsia - LepB gene for signal peptidase is similar in R. rickettsii, R. typhi

SARS - Alliance with NIH, USARMID targets discovery of therapeutics against SARS

Sickle Cell Anemia - Patient enrollment completed for phase II ICA-17043 trial

Sickle Cell Disease - Hemoxin issued orphan drug status by U.S. FDA

Stem-Cell Research - A novel technique enhances embryonic and neuronal stem-cell labeling

Stem-Cell Research - CD184 and alpha4beta1 integrins mediate CD34+ cell pseudoemperipolesis

Stem-Cell Research - Hematopoietic cell Hmgb3 expression prevents myeloid and B-cell differentiation

Stem-Cell Research - Inhibition of p21 expression can aid hematopoietic cell expansion

Stem-Cell Research - Mobilized HSCs later return to marrow

Stem-Cell Research - Novel EGFP reporter mouse line useful for hematopoietic cell study

Stem-Cell Research - Somatic nucleus reprogramming may be feasible

Stem-Cell Transplantation - Antithymocyte globulin improves outcome for unrelated stem-cell transplantation

Stem-Cell Transplantation - Beta-blockers may ameliorate GAVE in SCT recipients

Stem-Cell Transplantation - N-acetyl-L-cysteine does not affect busulfan pharmacokinetics

Stem-Cell Transplantation - Serial cytokine monitoring can help identify GVHD patients

Stem-Cell Transplantation - Serum stem-cell growth factor levels useful for monitoring post-SCT recovery

Stock Listing - Safety syringe company to apply for OTC Bulletin Board

Streptococcal Infections - Toxic shock syndrome may be treatable with IVIG therapy

Stroke - Immunoliposomes can reduce hemorrhage risk after tPA treatment for stroke

Systemic Lupus Erythematosus - Anti-SOD autoantibodies may allow damage by radicals in SLE

Thymocyte Differentiation - TCR signal strength controls GATA-3 levels, regulating T-cell differentiation

Toxic Shock Syndrome - TSS toxin-1 has a novel domain of the SAG molecule that binds MHC-II

Transplant Medicine - M-T7 protein from myxoma virus may attenuate transplanted kidney rejection

Transplant Medicine - Pregnancy outcome is good following functionally stable kidney transplants

West Nile Virus - Deal signed to share development of West Nile virus hyperimmune globulin

West Nile Virus - NIAID opens innovative treatment study

West Nile Virus - New test quickly diagnoses virus infection

Wiskott-Aldrich Syndrome - Wiskott-Aldrich syndrome protein binding inhibits tyrosine protein kinases

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