Blood Substitute
Novel LC-based assay detects Hemopure doping in athletes
Published in Blood Weekly, October 2nd, 2003
"Since January 2000, hemoglobin-based oxygen carriers, such as Hemopure, belong to the list of prohibited substances of the International Olympic Committee," scientists in Germany explained. "Hemopure is based on bovine hemoglobin, which is intra- and intermolecularly cross-linked by glutaraldehyde units causing an average molecular weight of approximately 250,000."
"Bovine and human hemoglobins differ by 15% in amino acid sequence; hence, tryptic digestion of these proteins generates species-common and -unique peptides," according to M. Thevis and...
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Source: Blood Weekly (2003-10-02)
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