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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . October 9th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem-Cell Transplantation - Erythropoietin reduces transfusion needs during aggressive lymphoma treatment

Stem-Cell Transplantation - Granisetron effective as antiemitic for bone marrow transplant recipients

Biomaterials - Platelet-rich plasma does not improve hydroxyapatite sinus grafting

Blood Substitute - Hemodilution with hemoglobin vesicle solutions can improve ischemic tissue oxygenation

Leukemia Therapy - High-dose hydroxyurea shows promise for treatment of high-risk AML patients

Stem-Cell Research - Allergy-induced CCR3 expression may stimulate bone marrow stem-cell migration

Acute Myeloid Leukemia - Functional FAS promoter polymorphisms are associated with increased risk of AML

Age-related Macular Degeneration - Rheopheresis reduces vessel-linked eye disease

Angiology - Fucoidan and heparin enhance growth factor-induced tube formation

Angiotensin - Basis of lisinopril-binding specificity in human ACE reported

Animal Models - Adult human blood stem cells can build human blood vessels in mice

Antiviral Therapy - Limitin is similar to but distinct from interferon-alpha as hepatitis C therapy

Apoptosis - Rel/NF-kappa B regulates B-cell apoptosis dependent on signals, cell stage

B-Cell Lymphoma - Prior lymphoplasmacytic lymphoma is linked to diffuse large B-cell lymphoma

Brain Cancer - Researchers identify cancer stem cell for brain tumors

Cancer Metastasis - Hemoglobin causes malignant cells to release matrix metalloproteinase-9

Cancer-related Anemia - Fatigue is common complaint of patients with cancer

Central Motor Disorder - Weakness, hand spasm can be multifocal motor neuropathy, treatable by IVIG

Drug Development - Ubiquitin-like peptide with anticancer and immunostimulatory activity isolated from mushroom

Factor XI Deficiency - Genetics to clinical management of factor XI deficiency reviewed

Factor XII Deficiency - Coagulation factor XII deficiency characterized in a Japanese family

Fanconi Anemia - OHSU scientists uncover key protein for susceptibility

Genetics - Antimicrobial peptides in our bodies have evolutionarily conserved functions

HIV Testing - FDA approves venipuncture whole-blood claim for OraQuick HIV-1 antibody test

HLA Alleles - HLA B*2714 and B*2708 alleles relate to spondarthritis and hemophilia

Hairy-Cell Leukemia - Hairy-cell leukemia can have CD10 positivity in a patient subset

Hematology - Hemostatic risk factors predict thrombosis during pregnancy and the puerperium

Hemochromatosis - Old drug works new tricks for iron overload heart disease

Hemodynamics - New technology permits bedside assessment of cerebral hemodynamics

Hemoglobin Monitoring - FDA clearance granted for new D-10 Hemoglobin testing system

Hemophilia A - Agreement signed with Baxter for Advate distribution

Hemophilia A - U.S. commercial availability of Advate announced

Hemophilia B - Clinical trials of Coagulin-B to resume

Hepatitis B and C - Risk posed by discarded needles and syringes

Hodgkin Disease - Routine CT scan is of little value in following patients with Hodgkin's disease

Human Antimicrobial Proteins - Leukocyte calprotectin has antimicrobial activity vs. Borrelia burgdorferi

Infectious Disease Diagnosis - Molecular blood test suitable for CMV monitoring

Intravenous Immunoglobulins - Antibody-deficient IVIg-treated patients have a rate of adverse effects of 0.8%

Ischemia-Reperfusion Injury - Heavy chain ferritin inhibits apoptosis, damage in experimental liver transplant

Kidney Disease - Pregnant patients with chronic renal insufficiency can have good outcome

Leukemia - Anthocyanidins induce apoptosis in human promyelocytic leukemia cells

Leukemia - Grants fund research on leukemia, lymphoma, and myeloma treatments

Leukemia - p15 Methylation has a poor prognostic impact on disease-free survival

Lipid Research - Company launches metabolic pathway maps and Signature flux equations

Lung Cancer - New blood test could detect disease in its earliest stages

Lymphocyte Activation - Quiescence enforcers for lymphocytes may be therapeutically useful

Lymphoma - Mutation of the BIK gene is a frequent feature of B-cell lymphomas

Lymphoma Therapy - Telomere shortening seen after chemotherapy in NHL patients

Mast-Cell Disease - Imatinib may inhibit the growth-promoting role of wild-type ckit

Menopause - Some anticoagulant therapies interact with hormone replacement therapy

Monoclonal Antibodies - Novel mAb may aid glycoprotein VI research

Myeloma - Researchers find genetic variations may predict treatment responses

Natural Killer Cells - There are two types of liver-restricted NKT cells for immune surveillance

Parkinson Disease - Therapeutic cloning tried in Parkinsonian mice

Personnel - Levin named to scientific advisory board at infectious disease firm

Polymerase Chain Reaction - Quantitative PCR assay for detecting Ehrlichia chaffeensis reported

Post-Transplant Infections - CMV DNA assessment may help early diagnosis in pediatric liver transplant

Proteomics - Type XIX collagen purified from human cord blood characterized

Sepsis - CE Mark issued for test that aids in sepsis risk assessment

Septic Shock - Therapy to combat septic shock mortality is based on limiting immune reactivity

Septicemia - Statin drugs may protect against sepsis

Sickle Cell Anemia - Children's Hospital of Pittsburgh reports successful bone marrow transplant

Stem Cells - Demand for cord blood bank rapidly growing in Taiwan

Stem Cells - Mouse sperm cells generated

Stem Cells - Patents issued for the therapeutic use of stem cells in gene therapy

Stem-Cell Research - Bone morphogenetic protein-7 regulates Runx2/Cbfa1 promoter transcription

Stem-Cell Research - Cystatin-B is expressed by both neural stem cells and mature neurons

Stem-Cell Research - Mesenchymal stem cells can regenerate craniofacial bone in animals

Stem-Cell Research - VEGF disruption affects tumors derived from stem cells and oncogenes differently

Stem-Cell Transplantation - T cell-depleted stem cell autografts can trigger CVID in genetically predisposed patients

Substance Abuse - Hepatitis C on the increase among injecting drug users

Systemic Lupus Erythematosus - Lupus can affect children with sickle cell disease

T-Cell Function - Fas ligand regulates different aspects of T -function, homeostasis

Thromboembolism - Many British oncologists unaware of cancer clot risk

Thrombosis - Deep vein thrombosis may be related to acute cytomegalovirus infection

Thrombosis - Thrombin upregulates ICAM-1 in human monocytes, THP-1 cells, and in pregnancy

Transfusion Medicine - Blood platelets may last longer on shelf

Transfusion Medicine - Suboptimal treatment contributes to bone loss in youth with beta-thalassemia

Transplant Medicine - Complement from renal allograft tubules may play largest role in rejection

Transplant Medicine - Mycophenolate mofetil added to a regimen with cyclosporine A will lower CsA

Transplant Medicine - Pediatric kidney transplantation improved in areas of infant survival, rejection reversal

Transplant Medicine - Racial groups fare equally well in kidney transplant using combination therapy

Transplant Medicine - Renal transplant artery stenosis reviewed

Trauma - Paper highlights blood substitute for trauma patients

Trypanosoma Brucei -  T. brucei has interrelated editosome proteins

Vesnarinone - Analysis of differentiation therapy might provide targeted molecules for therapy

West Nile Virus - Test helps protects the nation's blood supply

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