Cancer Metastasis
Hemoglobin causes malignant cells to release matrix metalloproteinase-9
Published in Blood Weekly, October 9th, 2003
According to recent research published in the journal Blood Coagulation and Fibrinolysis, "matrix metalloproteinase-9 (MMP-9) plays a crucial role in both angiogenesis and tumor invasion. Vascular endothelial growth factor (VEGF) has been shown to upregulate the expression of MMP-9 in vascular smooth muscle cells. We recently reported that hemoglobin (Hb) enhances the expression of tissue factor (TF) and VEGF on TF-positive human malignant cells."
"Therefore, to explore the relationship between tumor cell angiogenic protein VEGF and MMP-9, we studied the effect of Hb on...
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Source: Blood Weekly (2003-10-09)
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