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HTLC Virus

HTLV-I-infected T-cell leukemia cells may not express Tax, may be immune evasion

Published in Blood Weekly, October 16th, 2003

Human T-cell leukemia virus type I infection leads to T-cell leukemia cells that may or may not express Tax; lack of it may be immune evasion mechanism.

According to recent research published in the journal Oncogene, "Human T-cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in about 5% of carriers after a long latent period.

"After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo, by actions of encoded viral proteins including Tax. However, leukemic cells frequently lack the expression of Tax by the genetic and epigenetic changes of HTLV-I provirus, suggesting that Tax is not always...

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