Published in Blood Weekly, October 16th, 2003
According to recent research published in the journal Oncogene, "Human T-cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in about 5% of carriers after a long latent period.
"After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo, by actions of encoded viral proteins including Tax. However, leukemic cells frequently lack the expression of Tax by the genetic and epigenetic changes of HTLV-I provirus, suggesting that Tax is not always...
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