Red Blood Cells

The C-terminal of anion exchanger is involved in traffic to the RBC membrane

Published in Blood Weekly, October 23rd, 2003

The C-terminal tail of human anion exchanger AE1 in red blood cells is involved in trafficking to the plasma membrane, but protein folding and reactivity are not affected until after removal of the first 20 amino acids.

According to published research from Canada, "The human anion exchanger AE1 (Band 3) is an abundant glycoprotein localized in plasma membrane of red cells and is responsible for the electro-neutral exchange of chloride for bicarbonate. In order to determine the role of the carboxyl-terminal tail of AE1 in its expression, function and trafficking to the plasma membrane, we generated a series of 5 constructs encoding truncation mutants missing the last 5...

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Source: Blood Weekly (2003-10-23)

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