Stem-Cell Transplantation
Sibling-donor stem cell grafts can resolve PNH
Published in Blood Weekly, October 23rd, 2003
PNH "is an acquired clonal disorder of hematopoietic stem cells associated with a somatic mutation in the phosphatidylinositol glycan complementation class A (PIG-A) gene," scientists in Germany explained. "The only curative option is an allogeneic stem cell transplant (SCT), although treatment is hazardous."
According to M. Ditschkowski and coauthors at the University Hospital in Essen, "A 46-year-old male patient with PNH and obvious signs of severe, progressive hemolysis was transplanted in July 2002 with highly purified CD34+ T-cell-depleted peripheral blood...
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Source: Blood Weekly (2003-10-23)
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