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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . October 30th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem-Cell Transplantation - Costimulation blockade induces hematopoietic chimerism, central tolerance in SCT patients

Stem-Cell Transplantation - Rituximab active against refractory chronic GVHD

Myeloma Therapy - Treosulfan shows promise for multiple myeloma treatment

Stem-Cell Research - A58 oncogene can immortalize hematopoietic cells

Stem-Cell Research - Hematopoietic and mature blood cells can differentiate into cardiomyocytes

Transfusion Medicine - Dipyridamole improves efficacy of plasma exchange in TTP patients

Anthrax - $3.5M grant from U.S. government used for drug to treat anthrax exposure

Asthma - Late asthma may be calmed by cyclosporin A; it eliminates Bcl-2 pos T cells

Autoimmune Disease - Normally, autoantibodies produced by B cell precursors are eliminated at checkpoints

Biosafety - University receives $18M for construction of biosafety facility

Blood Analysis - Medical device manufacturer closes blood analysis product line acquisition

Blood Coagulation - Protease-activated receptor-1 agonists mimic angiogenic activation

Blood Products - Prestorage leukocyte reduction advised for autologous donation

Blood Substitute - Oxygen binding of cross-linked bis-hemoglobins evaluated

Blood Testing - Serologic T. cruzi test suitable for field, blood bank use

Cancer Therapy - Panzem formulation selected enhances bioavailability

Cardiology - Fusion between recipient- and donor-derived cells is a rare occurrence

Chronic Kidney Disease - New guidelines on bone disease in CKD address deficiencies

Colorectal Cancer - InSure test significantly increases patient participation in screening

Cord Blood - Biotech company receives cord blood to enhance stem-cell expansion technology

Deep Vein Thrombosis - ActiveCare DVT System now available

Dendritic-Cell Activation - CD1 and MHC-II molecules are in mature DC, despite lysosome reorganization

Dendritic-Cell Formation - TNF controls monocyte differentiation; dendritic cells form versus macrophages

Dengue Fever - Dengue fever outbreak occurs in Palau, Western Pacific

Environmental Health - Polybrominated and polychlorinated compounds found in human breast milk

Finance - Reagent company earns $3.7 million in net income in first quarter

Gene Transfer - GPI-anchored TFPI-1 alters tissue factor induced coagulation

Heart Disease Initiatives - Commission launches new research projects to combat cardiovascular disease

Heart Failure - Blood volume analyzer purchased by New York medical center

Heart Transplant Risk - A regimen without prednisolone in heart transplant may lower bone disease

Hematology - Bone marrow angiogenesis is implicated in hairy cell leukemia progression

Hematology - Brain morphogenetic gene Otx1 plays unexpected role in hematopoiesis

Hematology - Glycosylation restores survival of chilled blood platelets

Hematology - Oxidized low-density lipoprotein stops VEGF-induced cell differentiation

Hematology - Platelet proteinase-activated receptors play a significant role in tumor growth

Hematology - Pro- and anticoagulant proteins decreased during childhood

Hematology - The cdx4 gene specifies hematopoietic cell fate

Immunology - Paper highlights preclinical results of HIV peptide vaccine

Infection - StaphVAX confirmatory-phase-III trial ahead of schedule

Leukemia - Gene profiling may lead to customized treatments for pediatric patients

Leukemia - New studies examine racial differences and outcomes for children

Lithium Test - FDA clearance granted to market InstaRead rapid test for psychiatric use

Liver Failure - Bioartificial liver support systems bridge the transplantation gap

Liver Failure - The premise of adoptive immunity via transplantation needs more exploration

Malaria Therapy - Paroxysm serum from P. vivax infection blocks P. falciparum maturation

Menorrhagia - Desmopressin may not increase local fibrinolytic activity during menstruation

Multiple Myeloma - Agreement reached on STR phase III registration trial

Multiple Myeloma - Proteasome inhibitors suppress IRE1alpha, lower XBP-1, leading to apoptosis

Multiple Myeloma - Therapeutic implications of apoptotic signaling in multiple myeloma reported

Obstetrics - Alloimmune thrombocytopenia can be detected and even treated in utero

Oncology - Genes on 17q may be involved in the pathogenesis of classical Hodgkin lymphoma

Orthopedics - Grant will further research on healing bone injuries

Patents - Biotechnology corporation granted patent for gene delivery technology

Personnel - Spence Young named as director of reimbursement and national accounts

Prenatal Testing - Company announces milestone in development of noninvasive Down syndrome test

Recall - Nationwide recall issued for device used to determine blood-clotting time

Regulatory T-Cell Deficiency - Foxp3 is the gene critical for development of regulatory T cells

Relocation - Biotech contract-research organization moves headquarters to Colorado

Renal Transplantation - Nonmitogenic CD3 antibody can be used to treat acute kidney allograft rejection

Stem-Cell Research - Embryonic stem cells produced via nuclear transfer of human somatic nuclei into rabbit oocytes

Stem-Cell Research - HOXB4 increases cell regeneration after in vivo stem-cell selection

Stem-Cell Research - MyoR inhibits embryonic cell differentiation

Stem-Cell Research - Overexpressed hepatocyte growth factor treats the heart following ischemia

Stem-Cell Research - Positional identity gene expression codes not preserved in cultured neural stem cells

Stem-Cell Research - SDNSF helps maintain lifelong neurogenesis

Stem-Cell Research - Use eggs, not embryos, to derive stem cells, say researchers

Stem-Cell Research - WiCell earns national designation

Stem-Cell Transplantation - HLA class I and II typing may improve SCT outcome

Stem-Cell Transplantation - SCT schedule affects post-transplant T-cell repertoire

Systemic Lupus Erythematosus - Lower TCR zeta-chain in SLE is due to alteration, reducing the halflife

T-Cell Adhesion - Attachment of T cells to collagen is altered by lovastatin, phospholipase C

T-Cell Attachment - CD28 and small Rho GTPase Cdc42 are involved in actin rearrangement by T cells

T-Cell Differentiation - Repressor of GATA may be involved in differential development of Th2, Tc2 cells

Thromboembolic Disease - Protein C pathway in infants and children reviewed

Toxicology - Acetaminophen restriction curbs new emergency liver transplants in the U.K.

Transdifferentiation - Stem cell versatility questioned

Transfusion Medicine - Internet-based global apheresis registry initiated

Transfusion Medicine - MDS Nordion licenses x-ray blood irradiation technology

Transplant Medicine - Spleen transplantation may induce tolerance, but GVHD can occur too

Transplantation - Interferon therapy prior to liver transplant curbs hepatitis C recurrence

Virology - The 5' untranslated region of GB virus C highlights genotypic differences

West Nile Virus - Most patients with West Nile virus encephalitis responded rapidly to ARB

West Nile Virus - Season saw screening weaknesses, a rash of polio-like cases

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