T-Cell Adhesion
Attachment of T cells to collagen is altered by lovastatin, phospholipase C
Published in Blood Weekly, October 30th, 2003
According to published research from Israel, "We previously reported that human IL-2 dependent T cell lines derived from very late antigen (VLA)-1+ CD45RO+ peripheral blood (PB) T cells adhere constitutively to collagen type IV, whereas lines from VLA-1- PB lymphocytes (L) adhere weakly.
"Here we report that the latter are induced to adhere by phorbol 12-myristate 13-acetate (PMA). Both PMA dependent and constitutive adhesion, including that of a Herpes Virus Saimiri (HVS) infected CD4+VLA-1+ clone (HVST) were inhibited by anti-VLA-1...
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Source: Blood Weekly (2003-10-30)
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