T-Cell Differentiation
Repressor of GATA may be involved in differential development of Th2, Tc2 cells
Published in Blood Weekly, October 30th, 2003
According to a study from Japan, "Chromatin remodeling of type 2 cytokine gene loci occurs during differentiation of naive CD4 and CD8 T cells into type 2 helper (Th2) and cytotoxic (Tc2) T cells.
"IL-4 production and histone hyperacetylation in IL-4-associated nucleosomes in developing Tc2 cells were significantly lower than those of Th2 cells; however, cytokine production and histone hyperacetylation of IL-5 and IL-13 genes were equivalent. Developing Tc2 cells expressed lower GATA3 levels and dramatically increased levels of repressor of GATA...
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Source: Blood Weekly (2003-10-30)
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