Transdifferentiation

Stem cell versatility questioned

Published in Blood Weekly, October 30th, 2003

Transplanted bone-marrow-derived cells (BMDCs) can fuse with other mature cell types in live mice, according to a new study. This research questions the rationale of some stem cell transplants as a genuine replacement therapy.

In culture, bone marrow cells are able to generate liver, heart and brain cells. In vivo, the same also appears to be true. Although some researchers believe the transition to be a genuine transformation of one cell type to another, others think that the transplanted cells fuse with host tissue, thereby taking on the characteristics of the host cell. Fusion had been shown to occur in vitro, and a study published in Nature earlier this year...

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Source: Blood Weekly (2003-10-30)

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