Published in Blood Weekly, November 13th, 2003
"Mast cells are the central mediating cells of allergic reactions," scientists in the United States explained. "Binding of allergen-specific IgE to high-affinity IgE receptor (FcepsilonRI) and subsequent binding of allergen by the IgE causes receptor cross-linking and activation."
"In a study examining the differential gene expression in human cord blood-derived mast cells (CBMCs) mediated by activation of FcepsilonRI both with IgE and IgE followed by cross-linking with alpha-IgE, the chemokine I-309 was found to be upregulated," according to H. Gilchrest and coauthors...
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