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Influenza

Influenza-associated encephalopathy may be linked to cytokine transcription

Published in Blood Weekly, November 13th, 2003

Influenza virus load does not influence development of encephalopathy, different levels of cytokine transcription in PBL does.

"Influenza-associated encephalopathy, a severe neurologic complication of influenza, is being reported more frequently in Japan. We investigated the transcription of cytokine genes in peripheral blood leukocytes (PBL) and compared patients with influenza and with encephalopathy or febrile convulsions and patients with influenza but without neurologic complications," researchers in Japan report.

"Quantitative PCR revealed that transcription in PBL of the interleukins IL-6 and IL-10, and TNF-alpha genes was upregulated to a...

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