Testicular Cytokine

Granulocyte-macrophage colony stimulating factor affects sperm motility

Published in Blood Weekly, November 13th, 2003

Sperm motility is enhanced by addition of glucose or fructose substrates, due to the action of GM-CSF present in male germ cells.

"The granulocyte-macrophage colony stimulating factor (GM-CSF) is a pleiotropic cytokine capable of stimulating proliferation, maturation and function of hematopoietic cells. Receptors for this cytokine are composed of 2 subunits, alpha and beta, and are expressed on myeloid progenitors and mature mononuclear phagocytes, monocytes, eosinophils and neutrophils, as well as in other nonhematopietic cells. We have recently demonstrated that bull spermatozoa express functional GM-CSF receptors that signal for increased glucose and Vitamin C...

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Source: Blood Weekly (2003-11-13)

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