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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . November 20th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

HIV/AIDS Cancer - Stem-cell autotransplantation safe for patients with HIV-related lymphoma

Immunology - Phospholipase C-L2 regulates B-cell receptor signaling

Multiple Myeloma - Triple stem-cell autotransplants effective for high-risk MM patients

Myeloproliferative Disease - IL-3 receptor signaling is dispensable for BCR-ABL-induced MPD

Stem-Cell Research - Umbilical cord vein is source of mesenchymal stem cells

Anemia Therapy - Darbepoetin alfa is novel erythropoiesis-stimulating protein

Arthritis - Reconstructive surgery safe after stem-cell transplantation for refractory RA

Autoimmune Disease - Pulmonary-renal syndrome is a life-threatening risk from autoimmune disease

Autoimmune Disease - Rheumatoid arthritis, systemic lupus erythematosus have new therapeutic targets

Blood Bank - Mediware awarded contracts for blood bank management systems

Blood Products - Hemophilia patients in Japan bear a novel subtype of GB virus C hepatitis G

Blood Supply - Defense Department awards grant for research to support frozen blood reserve

Cardiovascular Gene Therapy - Adenoviral-transduced MSCs useful for eNOS gene transfer

Cell Biology - Study identifies stem cell in artery wall

Collaborations - Dialysis firm signs agreement with large provider

Cryptosporidium Gastroenteritis - Hyper-IgM syndrome is resolvable with bone marrow transplant; infections stop

Cytokine Secretion - Monocytes secrete MIF cytokine by a non-ER pathway, by an ABCA1 transporter

Dialysis - JMS dialysis machine may contribute to preventing medical accidents

Fancomi Anemia - Novel lentiviral vector efficiently transduces FA stem cells

Finance - Blood processing company reports second quarter results, reaffirms fiscal year guidance

Finance - Tissue regeneration company announces record third quarter results

Genomics - Pseudotyped adeno-associated virus vectors look suited for liver gene therapy

Graft-versus-Host Disease - Hematopoietic growth factor treatment does not increase GVHD risk

Graves Hyperthyroidism - Serum TNF-alpha receptor I can be a marker for active thyrotoxic Graves disease

HLA Regulation - Class II transactivator regulates classical HLA-DR; other MHC-II have alternates

Heart Disease - Clinic says new diagnostic test predicts cardiac risk up to 6 months ahead

Heart Transplant Risk - Transplant related coronary artery disease is linked to TNF-alpha, IFN-gamma

Hematologic Malignancies - Phase IB clinical trial initiated for stem cell transplants

Hematology - Endothelial precursor cells may be a better model for tumor endothelium

Hematology - Gene-deleted vector corrects a canine version of human hemophilia

Hematology - Glycoprotein Ib-binding protein from pit viper characterized

Hematology - HMX1 regulates intracellular heme levels in Saccharomyces

Hematology - Iranian hemodialysis patients are at high risk for acquiring HCV infections

Hematology - Nematode anticoagulant protein targets blood coagulation factor

Hematology - Novel preparation of heparins specific to factor Xa reported

Hematology - Transjugular liver biopsy is safe for patients with certain bleeding disorders

Hemodialysis - Renal failure patients on hemodialysis may not have altered periodontal status

Hemoglobin Oxidation - Oxidation of RBC hemoglobin produces higher pre-beta globin, low beta-globin

Hemophilia A - Advate receives unanimous positive opinion for marketing in Europe

Immunology - HBV gene changes precipitate viral breakthrough after liver transplantation

Infection Prevention - Catheter medication clinical trial to begin

Intestinal Lymphoma - Free perforation can occur in intestinal lymphoma and celiac disease

Kidney Function - Vascular permeability factors may play a role in kidney disease

Kidney Transplantation - Recombinant human erythropoietin can be used at any level of kidney function

Kidney Transplantation - Specific T-cell chemokine receptors, ligands occur in transplant glomerulopathy

Leukemia - AML cells overexpress PYST2

Leukemia - Leukemia, lymphoma cells prefer extravasation by means of laminin isoforms 8, 10

Leukemia - Targeted therapy of FLT3 may help the fight against leukemia, other malignancies

Lymphoma Therapy - Salvage allo-SCT effective for lymphoma patients who relapse after auto-SCT

Mathematical Modeling - Evolution of virulence of microparasites appears to be due to multiple factors

Mergers and Acquisitions - Historical Autographs U.S.A. to acquire biomedical device company

Metastasis - Stem cells shed light on cancer's spread

Multiple Myeloma - The angiogenic response in CAM assays is sometimes time-dependent

Myelodysplastic Syndrome - Loss of PIASy stem-cell expression may be involved in MDS pathogenesis

Obstetrics - Artery embolization before hysterectomy for placenta accreta reduces blood loss

Obstetrics - The prostaglandin analogue misoprostol manages postpartum hemorrhage

Oncology - RNA assays detect HCV infections better in those with non-Hodgkin lymphoma

Personnel - James J. Rahal, MD, West Nile virus expert, named to scientific advisory board

Personnel - Marrow transplant surgeon to chair medical and scientific advisory board

Potential Anti-inflammatory - Antiprotozoan drug imidocarb upregulates macrophage expression of IL-10

Protein Kinase Receptor - RACK-1 functions as a scaffold protein in cytokine signalling complexes

Pulmonary Medicine - Heme oxygenase-1 and carbon monoxide in pulmonary medicine reviewed

Regulatory Proteins - Notch is involved in proliferation, TCR activation, IFN-gamma product in T cells

Rheumatoid Arthritis - Blood and genetic sample bank available for rheumatoid arthritis research

SIDS - Beta-casomorphin penetration of the blood brain barrier may lead to apnea, SIDS

Sepsis - Improvement during first 24 hours is critical to survival of severe sepsis

Stem-Cell Research - A mathematical model offers insight into the promise of antiangiogenic therapy

Stem-Cell Research - Brain-derived neurotrophic factor enhances differentiation of grafted neural stem cells

Stem-Cell Research - Immature stem-cell populations in cord blood and bone marrow characterized

Stem-Cell Research - Neural crest stem-cell defects in TrkC null mice identified

Stem-Cell Research - Pluripotent stem cells isolated from mouse inner ear

Stem-Cell Research - Role of CD43 in cell-cell adhesion elucidated

Stem-Cell Research - TGF-beta triggers cell cycle arrest in CD34(+)CD38(-)c-kit(high) stem cells

Stem-Cell Transplantation - Ganciclovir treatment raises risk of CMV disease after SCT

Stem-Cell Transplantation - Human platelet antigen mismatch does not affect SCT outcome

Stem-Cell Transplantation - IL-7 enhances peripheral T-cell recovery in stem-cell allograft recipients

Stem-Cell Transplantation - Mathematical model of PBSC kinetics may improve harvest

Stem-Cell Transplantation - Non-MHC genes also influence HSCT outcome

Stem-Cell Transplantation - PCR platelet chimerism analysis can prevent unnecessary transfusions in pediatric SCT patients

Stroke - Treadmill exercise may suppress hippocampal apoptosis following stroke/ischemia

T-Cell Activity - A regulatory T-cell subset in gut lymphoid tissue has specific immune functions

T-Cell Adhesion - T-cell immunoactivity may be modulated by beta subunit of LFA-1's adhesiveness

Thrombosis - Curacyte awarded grant to fund development of factor Xa inhibitors

Tolerance Induction - Signals are jammed in T-cell receptors with too much antigen; tolerance emerges

Transfusion Medicine - Companies seek to enhance security of transfusions through positive patient ID

Transplant Medicine - Bone cells help call the shots for the blood's stem cells within

Transplant Medicine - Cytomegalovirus infection in kidney transplant precedes rejection in 36% cases

Transplant Medicine - HLA-C matching, allele variation are important in liver transplant rejection

Transplant Medicine - New guidelines published on unrelated marrow transplants

Transplant Medicine - Regulatory CD4, CD25 pos T cells will be the future of rejection prevention

Transplant Medicine - Topical tacrolimus may help resolve cutaneous chronic graft-versus-host disease

Transplantation - Undetected tumors won't change cancer-related liver transplant outcomes

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