HLA Regulation

Class II transactivator regulates classical HLA-DR; other MHC-II have alternates

Published in Blood Weekly, November 20th, 2003

HLA-DO in B cells is not regulated by only known factors, there are still some unknown; and many classical MHC-II genes are not regulated only by CIITA and can be expressed without it.

"The class II transactivator (CIITA) regulates expression of the classical and non-classical MHC class II genes, HLAs DR, DP, DQ and DM, but not the B cell-specific HLA-DO," investigators in the United States report.

"Here we show that only HLA-DR expression is completely dependent on CIITA, since residual expression of DM, DP and the beta chain of DQ was observed in CIITA-deficient RJ2.25 cells. Although DO shows a unique expression pattern compared to other MHC class...

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Source: Blood Weekly (2003-11-20)

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