Published in Blood Weekly, November 20th, 2003
According to recent research published in the American Journal of Cardiology, "Long-term success of cardiac transplantation is mainly limited by the development of transplant coronary artery disease (CAD); it is generally accepted that it is immune mediated, involving cytokines and growth factors.
"We show that development of transplant CAD is associated with a particular cytokine profile in myocardial biopsies characterized by a late (i.e., 1 yr) increase in tumor necrosis factor-alpha and interferon-gamma...
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