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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . November 27th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Multiple Myeloma - Recombinant erythropoietin enables stem cell autografting without RBC transfusions

Stem-Cell Transplantation - Granulocyte transfusions can prevent post-SCT infections

Hematology - Superparamagnetic labeling enables stromal cell tracking

Multiple Myeloma - Ho-166-DOTMP with stem-cell autografting shows promise against MM in early studies

Multiple Sclerosis - Immunosuppression therapy with stem-cell transplant ineffective in severe progressive MS

Stem-Cell Transplantation - Infliximab shows promise for treatment of gastrointestinal GVHD

AIDS Co-infections - Data: Hepsera associated with sustained reductions in hepatitis B virus

Allergy Medicine - Aqueous extract of Xanthii fructus may calm mast cells, stop anaphylaxis

Antigen Presentation - Polymorphonuclear neutrophils have many functions including antigen presentation

Awards - NewsRx wins 2003 eHealthcare Leadership awards

Biclonal T-Cell Expansion - Monoclonal EBV infects T cells, expands one or more clones in active infection

Bioengineering - Heparin and alginate crosslinked gel microparticles stimulate remodeling

Blood Clotting Disorders - FDA clears 11 diagnostic tests for risk of cardiovascular disease

Chemical Sensitization - Epidermal Langerhans cells induce chemical sensitization; under cytokine control

Cirrhosis - Hepatitis C virus reinfection speeds rejection after liver transplantation

Collaborations - $90M hematology agreement signed

Corporate Update - Gene therapy company reports on drug development, finances

Dendritic Cell Maturation - Viral infection or dsRNA induce specific maturation pathways in dendritic cells

Dermatology - Endemic pemphigus foliaceus patients have a Th2 bias and high IL-1 production

Diabetes Medicine - Blood cells that are CD34+ help diabetic mouse skin wounds to heal faster

Diagnostics - Thymocyte populations can be analyzed for all nuclear proteins by flow cytometry

Echocardiography - Atrial thrombosis can be slowly resolved without embolism by warfarin, aspirin

Environmental Health - Vanadium(IV) tetraoxide has genotoxic effects on peripheral blood cells

Fetal Immune System - Human fetus has active immune system and unique CD95-CD45RO+ T-cells

Finance - Blood systems developer reports loss of $0.64 per share

Finance - Testing products company reports 22% increase in revenues during third quarter

Hematology - C-type lectin from venom of Crotalus durissus terrificus characterized

Hematology - Thrombophilia and venous thromboembolism warrant therapy in pregnant women

Hepatitis B - Positive 1-year data on telbivudine presented for the treatment of chronic HBV

Hepatitis B - Prophylactic therapy makes renal transplantation safe for hepatitis B patients

Hepatitis C - Positive data reported on IDN-6556 for liver impairment in HCV patients

Hepatitis C - Study investigates Pegasys and Copegus in African Americans

Hepatitis C - Study shows benefits of therapy in previously under-treated patient population

Immunogenicity - Therapeutic biologicals must be developed without unwanted immunogenicity

Immunology - Genzyme enters joint effort to develop therapies for immune-mediated diseases

Immunology - Higher steroid doses improve liver function during acute rejection episodes

Immunology - Monocytes can be separated from buffy coats following a simple three-step method

Insect-borne Disease -  Trypanosoma cruzi, T. rangeli is distinguishable by PCR in human, insect

Kidney Disease - Nationwide screening reveals high kidney disease rates, low awareness level

Leukemia - Comprehensive gene profiles hold promise for improving outcomes

Leukemia - Scientists identify enzyme with key role in leukemia protein's normal function

Leukocytes and Cannabinoids - Polymorphonuclear leukocytes don't have receptor nor respond to cannabinoids

Liver Repair - The complements C3a and C5a appear to be necessary for liver regeneration

Liver Transplantation - Living liver donors increase the risk for cholestasis in graft recipients

Lung Transplants - Modified lung donor standards increase donor pool, decrease mortality

Lymphadenitis - Histiocytic necrotizing lymphadenitis is a common occurrence, not well studied

Lymphoma - Murine model of human anaplastic large-cell lymphoma developed

Lymphoma Therapy - High-dose radioimmunotherapy may be superior to standard follicular lymphoma treatment

Lymphoma Therapy - Posttransplant HHV8 infection remains a problem for bone marrow graft recipients

Melanoma - Antiplatelet drug blocks bone tumor metastases in mice

Multiple Sclerosis - Gelatinase B/MMP-9 produces an antigenic peptide from alpha B-crystallin

Multiple Sclerosis - Myelin oligodendrocyte glycoprotein, an MS autoantigen, is in dimer form

Myocardial Infarction - Bone marrow stem cells can reduce ischemia-induced cardiac damage

Natural Killer Function - NKT cells react to glycolipids by downregulating surface receptors, expanding

Nonmyeloablative Transplant - Pentostatin appears to induce safe lymphodepletion for stem-cell transplant

Obstetrics - Oxytocin in prefilled injection devices is convenient for home deliveries

Occupational Health - Aerosols generated during dental debonding may transmit hepatitis B infection

Oxygen Therapeutic - Company to respond to FDA's questions on Hemopure

Psychiatric Disorders - Prevalence of antibodies to neurotransmitter receptors may affect mental health

Psychiatric Pseudoinfection - Clozapine therapy can cause inflammation, possible Ig-mediated hypersensitivity

Pulmonary Inflammation - Peripheral benzodiazepine receptor ligands appear to benefit pneumopathy

SARS - Severe acute respiratory syndrome produces lymphopenia, immunodeficiency

Staphylococcus Aureus -  S. aureus may affect Wegener granulomatosis through lymphoid interactions

Stem-Cell Research - A functional assay for epidermal stem cells should open up research options

Stem-Cell Research - Akt signaling regulates side population cell phenotype through Bcrp1 expression

Stem-Cell Research - FLIP prevents apoptosis in quiescent erythroid progenitors

Stem-Cell Research - Human stem cell work may start in 5 years

Stem-Cell Research - Recombinant SCF used to identify c-kit+ porcine marrow progenitors

Stem-Cell Research - Researcher to make 17 new cell lines available to research community

Stem-Cell Transplantation - Dendritic cell function impaired after reduced-intensity conditioning

Stem-Cell Transplantation - Post-SCT calcineurin inhibitor-induced CNS toxicity has poor long-term outcome

Stem-Cell Transplantation - Quantitative real-time PCR improves post-SCT CMV detection

Supply Agreements - Antibody-manufacturing agreement signed with BioE

T-Cell Subsets - Ionomycin-resistant, CD4+ T cell subset in PBMC may be multidrug resistant

Thrombocytopenia Purpura - Anti-idiotypic antibodies to antiplatelet antibodies are common in idiopathic TP

Transfusion Medicine - Endothelin-1 reverses hemorrhagic hypotension in rats

Transfusion Medicine - Intraoperative autologous transfusion device expensive but ineffective

Transfusion Safety - Strategic alliance to market Donor-ID and Transfuse-ID

Transplant Medicine - Daclizumab, tacrolimus, and mycophenolate mofetil are safe for second transplant

Transplant Medicine - Donor-transmitted malignancy highlights a need for organ procurement vigilance

Transplant Medicine - Large B-cell malignancy, Castleman disease involve HHV-8, EBV post-transplant

Transplant Medicine - Piggyback transplant involving liver may risk post-transplant pulmonary embolism

Transplant Medicine - Post-transplantation lymphoproliferative disorders are mostly caused by EBV

Transplant Medicine - Sensitive PCR assay will allow monitoring of human herpesviruses 6A, 6B, and 7

Transplant Research - Ethylcarbodiimide-treated dendritic cells prolong organ graft survival

Tuberculosis Diagnostics - Blood culture suitable for diagnosis of disseminated TB

Ubiquitination Disorder - TNF-alpha controls NEMO ubiquitination; NEMO zinc finger mutation alters this

Vaccine Safety - Recommended immunization of patients with bleeding disorders outlined

West Nile Virus - West Nile encephalitis reported in two hematopoietic stem-cell graft recipients

Women's Health - Immunoglobulin-secreting cells are more frequent during the periovulatory stage

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