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Hematology

C-type lectin from venom of Crotalus durissus terrificus characterized

Published in Blood Weekly, November 27th, 2003

Researchers have completed an initial structural analysis of an alpha4 beta4 C-type lectin from the venom of Crotalus durissus terrificus.

"Convulxin, an alpha-beta C-type lectin, is a potent platelet activator isolated from the venom of the South American rattlesnake Crotalus durissus terrificus. It is a 26.5-kDa alpha-beta heterodimer consisting of two homologous disulfide-linked chains," researchers in Brazil report.

"The crystals belong to space group I4, with unit-cell parameters a=b=131.61, c=121.85 Angstrom, and diffraction data were collected to 2.7 Angstrom," reported Mario T. Murakami and colleagues at...

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