Published in Blood Weekly, November 27th, 2003
Acute and chronic GVHD "remain major barriers to successful hematopoietic stem-cell transplantation (SCT)," scientists in the United States noted. "TNF-alpha has been implicated in the pathogenesis of GVHD and TNF-alpha blockade has been explored for treatment of GVHD. The development of a chimeric mouse/human monoclonal antibody (infliximab) which binds to cells producing TNF-alpha, allowing for not only the neutralization of TNF-alpha but also lysis of the cells producing the TNF-alpha, makes this an attractive drug to explore in GVHD."
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