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Thrombocytopenia Purpura

Anti-idiotypic antibodies to antiplatelet antibodies are common in idiopathic TP

Published in Blood Weekly, November 27th, 2003

Anti-idiotypic antibodies to antiplatelet antibodies to GPIIb/IIIa are common in idiopathic thrombocytopenia purpura; blocking produces remissions.

According to a study from India, "The severity and clinical course of idiopathic thrombocytopenic purpura (ITP) varies from patient to patient. The factors responsible for this variation are not well understood. In this study we attempted to evaluate the role of anti-idiotypic antibodies in the immunoregulation of the disease.

"We investigated 114 cases of chronic ITP in adults. We determined anti-idiotypic antibodies against antiplatelet antibodies using idiotype-binding ELISA, paratope-blocking ELISA,...

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