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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . December 4th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Stem-Cell Transplantation - Allogeneic RIST could be outpatient procedure

Transfusion Medicine - Granulocyte transfusions effective against drug-resistant infection in neutropenic patient

Lymphoma Therapy - Involved field radiation therapy raises TRM risk in stem-cell transplant recipients

Stem-Cell Research - Key components of hematopoietic stem cell niche identified

Stem-Cell Transplantation - CXCR4 antagonist mobilizes CD34+ cells

Stem-Cell Transplantation - Natural killer cell chimerism may mark children with high graft rejection risk

AIDS Prevention - China can use lessons from anti-SARS battle to take on AIDS, U.N. expert says

Acquired Hemophilia - Acquired factor VIII inhibitor-related can occur with myelodysplastic disorder

Acute Myocardial Infarction - Newer formulation of heparin improves outcomes for suspected MI patients

Addiction Medicine - Methadone users need access to orthotopic liver transplantations

Adverse Drug Effect - Growth hormone therapy may kill; monocytes produce IL-1alpha, IL-6, TNFalpha

Adverse Drug Effects - Eprex induces reversible antierythropoietin antibodies and red cell aplasia

Antifungal Therapy - Improved diagnosis of fungal infections no longer requires preventive therapy

Atrial Myxoma - Myxoma of the right atrium could be due to fusion of giant cells

B Cell Maturation - Transgenic work shows lack of lambda5 doesn't fully impair pro-B cell maturation

B-Cell Function - Delta BAFF is an alternate splice isoform of BAFF that regulates B cells

Bernard-Soulier Syndrome - Unresponsive thrombocytopenia patients may have GPIX mutation, Bernard-Soulier

Blood Safety - New Jersey blood bank shipping plasma to Scotland amid mad cow worries

Blood Substitute - Perfluorocarbon-based blood substitute undergoes phase I clinical trial

Brain Cancer Therapy - Ruta 6 induces selective apoptosis in glioma cells

Cancer Therapy - Risk of second malignancy high after HDT and stem-cell autotransplantation

Cell Therapy - World's first integrated system to increase safety of cell therapy

Chronic Hepatitis C - Tissue regeneration may drive HCV recurrence after liver transplantation

Chronic Kidney Disease - Company launches trial of gene-modulated tissue production of protein

Collaborations - Haemonetics announces intent to sign distribution agreement with French firm

Colon Cancer - High expression of CD55 by colorectal cancers is predictive of low survival

Coronary Artery Bypass - Successful intracoronary bone marrow cell transplant leads late-breaking clinical trials

Critical Care Medicine - Pressures' variations comparable as blood loss indicators in mechanically ventilated patients

Dendritic Cell Subsets - CD11b+ DC from Peyer patch induce the highest B cell IgA secretion via IL-6

Diagnostics - Peripheral blood mononuclear cells express different genes in kidney cancer

Down Syndrome - Chromotest updates presented at American Society of Human Genetics meeting

Epstein-Barr Virus - Severe pneumonitis, cerebral hemorrhage is a risk with Epstein-Barr virus

Gastroenterology - Outcomes with hepatitis C- and B-core antibody-positive grafts are good

Gene Rearrangement - TCR gene rearrangement can occur outside thymus, in the human small intestine

Genetic Screening - Genetics company presents new data relating to prenatal and genetic testing

HIV Diagnostic - Investigational device exemption application submitted for HIV-1 test

HIV/AIDS Immunotherapy - IL-7 safely stimulates T-cell renewal in SIV-infected macaques

HIV/AIDS Therapy - LC/MS/MS assay suitable for measuring atazanavir levels in peripheral blood

Hematology - Endothelial progenitor cells respond to shear stress with accelerated activity

Hematology - Silver(I) ion exerts unusual aggregation effects on hemoglobin

Hematopoietic Cell Transplant - Keeping DC immaturity may induce tolerance for transplant of hematopoietic cells

Hematopoietic Cytokines - Cytokines are recognized by gp130 by thermodynamics, independent of structure

Hemolysis - Unfolding of Vibrio cholerae hemolysin induces toxin monomer oligomerization

Hemophilia - Supplement filed for approval of needless device used with Kogenate FS

Hemorrhagic Complications - Non-hemophiliacs can have acquired, temporary hemorrhagic factor VIII syndrome

Human Herpesvirus 7 - Glycoproteins B, H of human herpesvirus 7 appear to have few polymorphisms

Immune Thrombocytopenia - I.V. anti-D safe for pregnant moms with thrombocytopenia purpura; fetus okay

Immune Tolerance - Stat3 molecule can regulate switch from T cell activation to immune tolerance

Immunoglobulin - New IGIV, Gamunex, now available

Immunology - Antisense blockade of Stat5a/b promotes the apoptosis of lymphoid cells

Immunology - Transparent fish provide window on blood formation and marrow transplantation

Immunosuppressive Drugs - Immunosuppressants influence dendritic cells; can affect tolerance induction

Infectious Prions - Prototype leukocyte reduction filter reduces infectious prions in study

Intestinal Disease - Celiac disease should be treatable by gluten-free diet and better immunotherapy

Islet Transplantation - Phase I/II study initiated treating diabetes with encapsulated replacement islets

Kidney Cancer - Reduced-intensity stem-cell transplantation may slow RCC progression

Lassa Fever - Researchers receive $1.68M grant for research on Lassa fever treatment

Leukemia - DNA microarray stem cell analysis can differentiate de novo and MDS-related AML

Leukemia Therapy - Cyclosporine and IFN-gamma treatment after auto-SCT improves outcome

Leukemia Therapy - Cytoreduction may be needed for curative SCT in CML patients

Leukemia Therapy - Imatinib treatment can improve SCT outcome in Ph+ ALL patients

Leukemia Therapy - Persistent iron overload common in long-term AML survivors after stem-cell autografting

Leukocyte Function - Some integrin antagonists bind the beta2 subunit I domain, directing signals

MHC-I Antigen - Chaperonin TRiC is essential for antigen presentation, protecting MHC-I antigen

Mast Cell Function - Human mast cells have Toll-like receptor 4, innate and adaptive immune responses

Muscular Dystrophy - Blood cells could build muscle in neuromuscular diseases

Occupational Exposure - Aromatic hydrocarbon-DNA adducts are higher in leukocytes of rickshaw drivers

Occupational Health - Healthcare workers experience a decline in blood and body fluid exposures

Parachlamydia Acanthamoeba - Free-living amoebic pathogen P. acanthamoeba replicates in macrophages

Patents - Court upholds stem-cell patents

Patents - Stem cell expansion technology receives patent in Australia

Personnel - Blood products company adds Dr. Steven Gerber and Robert Chilton to team

Policy - Clinical use of embryonic stem cells jeopardized by Bush's funding

Probiotic Benefit -  Bifidobacterium DNA induces PBMC IL-10; reduces gut IL-1, increases IL-10

Public Health - Blood center warns that increasing donor deferrals threatens blood supply

Scleroderma Diagnostics - Pulmonary fibrosis, hypertension may be due to anti-endothelial antibodies

Sex Hormones - Delayed neutrophil apoptosis occurs with female sex hormones, also increased ROI

Stem Cells - Company receives U.S. patent for stem-cell culture medium

Stem-Cell Research - Bone marrow-derived cells offer little hope for repairing damaged livers

Stem-Cell Research - First analysis of hematopoietic stem cell proteome completed

Stem-Cell Research - Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis

Stem-Cell Research - Osteoblastic cells regulate hematopoietic stem cell niche

Stem-Cell Research - Stat5 involved in hematopoietic commitment of embryonic stem cells

Stem-Cell Research - The power of adult stem cells can be harnessed for tissue repair

Stem-Cell Transplantation - Conditioning regimen strongly influences post-SCT IPS risk

Stem-Cell Transplantation - Data on AMD3100 to be presented at ASH

Stem-Cell Transplantation - Despite complete chimerism, post-BMT mesenchymal stem cells lack donor genotype

Stem-Cell Transplantation - Infliximab raises post-SCT risk of non-Candida invasive fungal infections

Stem-Cell Transplantation - Low CsA levels, methotrexate use linked to heightened aGVHD risk in children

Stem-Cell Transplantation - Post-PBSCT leukocyte and cytokine profiles determined

Stem-Cell Transplantation - Results of bone marrow and PBSC donation compared

Streptococcus Pyogenes -  Streptococcus pyogenes HtsA, upregulated in blood, binds one heme molecule

T-Cell Function - Intron 3 of TNF-alpha gene controls cytokine expression by specific cell types

T-Cell Homeostasis - All CD8+ T cells respond to IL-15 with expansion and cytotoxic function

T-Cell Maturation - IKK2 is necessary for development of regulatory, memory, peripheral T cells

Teen Pregnancy Risk - Folate, vitamin B-12, and iron can all be compromised in pregnant adolescents

Thyroid Tumor Diagnostics - Galectin-3 is expressed in higher amount only in papillary thyroid carcinomas

Tolerance Induction - High ILT3, ILT4 expression characterizes dendritic cells that are tolerized

Tolerance Induction - Recognition of antigens on regulatory CD4+ T cells aid tolerance induction

Transplant Medicine - Crystalline particles seen in University of Wisconsin perfusion solution

Transplantation - HCV recurrence reflects low sequence diversity after liver transplantation

Transplantation - Neither liver transplantation nor HCV contraindicate renal transplant

Transplantation - Where livers and kidneys are both needed liver transplants should be done first

Vascular Disease - Company initiates multidose phase I clinical trial with GH9001

Von Willebrand Disease - Evolutionary link proposed between WARP and FACIT-like collagens

West Nile Virus - West Nile virus assay detects more than 800 infected blood donations

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